Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE)
Reiter R, Wetzel M, Hamesch K, Strnad P, Asbach P, Haas M, Siegmund B, Trautwein C, Hamm B, Klatt D, Braun J, Sack I, Tzschaetzsch H (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 13
Article Number: e0196486
Journal Issue: 4
DOI: 10.1371/journal.pone.0196486
Abstract
Purpose Although it has been known for decades that patients with alpha1-antitrypsin deficiency (AATD) have an increased risk of cirrhosis and hepatocellular carcinoma, limited data exist on non-invasive imaging-based methods for assessing liver fibrosis such as magnetic resonance elastography (MRE) and acoustic radiation force impulse (ARFI) quantification, and no data exist on 2D-shear wave elastography (2D-SWE). Therefore, the purpose of this study is to evaluate and compare the applicability of different elastography methods for the assessment of AATD-related liver fibrosis. Methods Fifteen clinically asymptomatic AATD patients (11 homozygous PiZZ, 4 heterozygous PiMZ) and 16 matched healthy volunteers were examined using MRE and ARFI quantification. Additionally, patients were examined with 2D-SWE. Results A high correlation is evident for the shear wave speed (SWS) determined with different elastography methods in AATD patients: 2D-SWE/MRE, ARFI quantification/2D-SWE, and ARFI quantification/MRE (R = 0.8587, 0.7425, and 0.6914, respectively; P≤0.0089). Four AATD patients with pathologically increased SWS were consistently identified with all three methodsÐMRE, ARFI quantification, and 2D-SWE. Conclusion The high correlation and consistent identification of patients with pathologically increased SWS using MRE, ARFI quantification, and 2D-SWE suggest that elastography has the potential to become a suitable imaging tool for the assessment of AATD-related liver fibrosis. These promising results provide motivation for further investigation of non-invasive assessment of AATD-related liver fibrosis using elastography.
Involved external institutions
Universitätsklinikum Aachen (UKA)
Germany (DE)
Humboldt-Universität zu Berlin
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Germany (DE)
Humboldt-Universität zu Berlin
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
How to cite
APA:
Reiter, R., Wetzel, M., Hamesch, K., Strnad, P., Asbach, P., Haas, M.,... Tzschaetzsch, H. (2018). Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE). PLoS ONE, 13(4). https://doi.org/10.1371/journal.pone.0196486
MLA:
Reiter, Rolf, et al. "Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE)." PLoS ONE 13.4 (2018).
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