Dittmann F, Tzschaetzsch H, Hirsch S, Barnhill E, Braun J, Sack I, Guo J (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 78
Pages Range: 976-983
Journal Issue: 3
DOI: 10.1002/mrm.26484
Purpose: To develop a compact magnetic resonance elastography (MRE) protocol for abdomen and to investigate the effect of water uptake on tissue stiffness in the liver, spleen, kidney, and pancreas. Methods: Nine asymptomatic volunteers were investigated by MRE before and after 1 liter water uptake. Shear-wave excitation at four frequencies was transferred to the abdomen from anterior and posterior directions using pressurized air drivers. Tomographic representations of shear-wave speed were produced by analysis of multifrequency wave numbers in axial and coronal images acquired within four breath-holds or under free breathing, respectively. Results: Pre and post water, stiffness of the spleen (pre/post: 2.20 ± 0.10/2.06 ± 0.18 m/s) and kidney (pre/post: 1.93 ± 0.22/1.97 ± 0.23 m/s) was higher than in the liver (pre/post: 1.36 ± 0.10/1.38 ± 0.13 m/s) and pancreas (pre/post: 1.20 ± 0.12/1.20 ± 0.08 m/s), all P < 0.01. Accounting for four drive frequencies, water drinking only changed the splenic stiffness (–6%, P = 0.03), whereas in the frequency range from 50 to 60 Hz the effect became significant also in the pancreas (–6%, P = 0.04) and liver (+3%, P = 0.03). Elastograms of the kidney in coronal view clearly depicted higher stiffness in cortex than in medulla. Conclusion: Tomoelastography reveals sensitivity of tissue mechanical properties to the hydration state of multiple abdominal organs within one scan and in unprecedented resolution of anatomical details. Magn Reson Med 78:976–983, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
APA:
Dittmann, F., Tzschaetzsch, H., Hirsch, S., Barnhill, E., Braun, J., Sack, I., & Guo, J. (2017). Tomoelastography of the abdomen: Tissue mechanical properties of the liver, spleen, kidney, and pancreas from single MR elastography scans at different hydration states. Magnetic Resonance in Medicine, 78(3), 976-983. https://doi.org/10.1002/mrm.26484
MLA:
Dittmann, Florian, et al. "Tomoelastography of the abdomen: Tissue mechanical properties of the liver, spleen, kidney, and pancreas from single MR elastography scans at different hydration states." Magnetic Resonance in Medicine 78.3 (2017): 976-983.
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