Higher-resolution MR elastography reveals early mechanical signatures of neuroinflammation in patients with clinically isolated syndrome
Fehlner A, Behrens JR, Streitberger KJ, Papazoglou S, Braun J, Bellmann-Strobl J, Ruprecht K, Paul F, Wuerfel J, Sack I (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 44
Pages Range: 51-58
Journal Issue: 1
DOI: 10.1002/jmri.25129
Abstract
Purpose: To assess if higher-resolution magnetic resonance elastography (MRE) is a technique that can measure the in vivo mechanical properties of brain tissue and is sensitive to early signatures of brain tissue degradation in patients with clinically isolated syndrome (CIS). Materials and Methods: Seventeen patients with CIS and 33 controls were investigated by MRE with a 3T MRI scanner. Full-wave field data were acquired at seven drive frequencies from 30 to 60 Hz. The spatially resolved higher-resolution maps of magnitude |G*| and phase angle φ of the complex-valued shear modulus were obtained in addition to springpot model parameters. These parameters were spatially averaged in white matter (WM) and whole-brain regions and correlated with clinical and radiological parameters. Results: Spatially resolved MRE revealed that CIS reduced WM viscoelasticity, independent of imaging markers of multiple sclerosis and clinical scores. |G*| was reduced by 14% in CIS (1.4 ± 0.2 kPa vs. 1.7 ± 0.2 kPa, P < 0.001, 95% confidence interval [CI] [–0.4, –0.1] kPa), while φ (0.66 ± 0.04 vs. 0.67 ± 0.04, P = 0.65, 95% CI [–0.04, 0.02]) remained unaltered. Springpot-based shear elasticity showed only a trend of CIS-related reduction (3.4 ± 0.5 kPa vs. 3.7 ± 0.5 kPa, P = 0.06, 95% CI [–0.6, 0.02] kPa) in the whole brain. Conclusion: We demonstrate that CIS leads to significantly reduced elasticity of brain parenchyma, raising the prospect of using MRE as an imaging marker for subtle and diffuse tissue damage in neuroinflammatory diseases. J. Magn. Reson. Imaging 2016;44:51–58.
Involved external institutions
Germany (DE)How to cite
APA:
Fehlner, A., Behrens, J.R., Streitberger, K.-J., Papazoglou, S., Braun, J., Bellmann-Strobl, J.,... Sack, I. (2016). Higher-resolution MR elastography reveals early mechanical signatures of neuroinflammation in patients with clinically isolated syndrome. Journal of Magnetic Resonance Imaging, 44(1), 51-58. https://doi.org/10.1002/jmri.25129
MLA:
Fehlner, Andreas, et al. "Higher-resolution MR elastography reveals early mechanical signatures of neuroinflammation in patients with clinically isolated syndrome." Journal of Magnetic Resonance Imaging 44.1 (2016): 51-58.
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