Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson's disease
Lipp A, Trbojevic R, Paul F, Fehlner A, Hirsch S, Scheel M, Noack C, Braun J, Sack I (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Book Volume: 3
Pages Range: 381-387
DOI: 10.1016/j.nicl.2013.09.006
Abstract
Detection and discrimination of neurodegenerative Parkinson syndromes are challenging clinical tasks and the use of standard T1- and T 2-weighted cerebral magnetic resonance (MR) imaging is limited to exclude symptomatic Parkinsonism. We used a quantitative structural MR-based technique, MR-elastography (MRE), to assess viscoelastic properties of the brain, providing insights into altered tissue architecture in neurodegenerative diseases on a macroscopic level. We measured single-slice multifrequency MRE (MMRE) and three-dimensional MRE (3DMRE) in two neurodegenerative disorders with overlapping clinical presentation but different neuropathology - progressive supranuclear palsy (PSP: N = 16) and idiopathic Parkinson's disease (PD: N = 18) as well as in controls (N = 18). In PSP, both MMRE (Δμ = - 28.8%, Δα = - 4.9%) and 3DMRE (Δ|G*|: - 10.6%, Δφ: - 34.6%) were significantly reduced compared to controls, with a pronounced reduction within the lentiform nucleus (Δμ = - 34.6%, Δα = - 8.1%; Δ|G*|: - 7.8%, Δφ: - 44.8%). MRE in PD showed a comparable pattern, but overall reduction in brain elasticity was less severe reaching significance only in the lentiform nucleus (Δμ n.s., Δα = - 7.4%; Δ|G*|: - 6.9%, Δφ: n.s.). Beyond that, patients showed a close negative correlation between MRE constants and clinical severity. Our data indicate that brain viscoelasticity in PSP and PD is differently affected by the underlying neurodegeneration; whereas in PSP all MRE constants are reduced and changes in brain softness (reduced μ and |G*|) predominate those of viscosity (α and φ) in PD. © 2013 The Authors.
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How to cite
APA:
Lipp, A., Trbojevic, R., Paul, F., Fehlner, A., Hirsch, S., Scheel, M.,... Sack, I. (2013). Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson's disease. NeuroImage: Clinical, 3, 381-387. https://doi.org/10.1016/j.nicl.2013.09.006
MLA:
Lipp, Axel, et al. "Cerebral magnetic resonance elastography in supranuclear palsy and idiopathic Parkinson's disease." NeuroImage: Clinical 3 (2013): 381-387.
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