Multifrequency inversion in magnetic resonance elastography
Papazoglou S, Hirsch S, Braun J, Sack I (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 57
Pages Range: 2329-2346
Journal Issue: 8
DOI: 10.1088/0031-9155/57/8/2329
Abstract
Time-harmonic shear wave elastography is capable of measuring viscoelastic parameters in living tissue. However, finite tissue boundaries and waveguide effects give rise to wave interferences which are not accounted for by standard elasticity reconstruction methods. Furthermore, the viscoelasticity of tissue causes dispersion of the complex shear modulus, rendering the recovered moduli frequency dependent. Therefore, we here propose the use of multifrequency wave data from magnetic resonance elastography (MRE) for solving the inverse problem of viscoelasticity reconstruction by an algebraic least-squares solution based on the springpot model. Advantages of the method are twofold: (i) amplitude nulls appearing in single-frequency standing wave patterns are mitigated and (ii) the dispersion of storage and loss modulus with drive frequency is taken into account by the inversion procedure, thereby avoiding subsequent model fitting. As a result, multifrequency inversion produces fewer artifacts in the viscoelastic parameter map than standard single-frequency parameter recovery and may thus support image-based viscoelasticity measurement. The feasibility of the method is demonstrated by simulated wave data and MRE experiments on a phantom and in vivo human brain. Implemented as a clinical method, multifrequency inversion may improve the diagnostic value of time-harmonic MRE in a large variety of applications. © 2012 Institute of Physics and Engineering in Medicine.
Involved external institutions
Germany (DE)How to cite
APA:
Papazoglou, S., Hirsch, S., Braun, J., & Sack, I. (2012). Multifrequency inversion in magnetic resonance elastography. Physics in Medicine and Biology, 57(8), 2329-2346. https://doi.org/10.1088/0031-9155/57/8/2329
MLA:
Papazoglou, Sebastian, et al. "Multifrequency inversion in magnetic resonance elastography." Physics in Medicine and Biology 57.8 (2012): 2329-2346.
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