A polyphenylene dendrimer drug transporter with precisely positioned amphiphilic surface patches

Stangenberg R, Wu Y, Hedrich J, Kurzbach D, Wehner D, Weidinger G, Kuan SL, Jansen MI, Jelezko F, Luhmann HJ, Hinderberger D, Weil T, Muellen K (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Advanced Healthcare Materials Wiley

Book Volume: 4

Pages Range: 377-384

Journal Issue: 3

DOI: 10.1002/adhm.201400291

Abstract

The design and synthesis of a polyphenylene dendrimer (PPD 3) with discrete binding sites for lipophilic guest molecules and characteristic surface patterns is presented. Its semi-rigidity in combination with a precise positioning of hydrophilic and hydrophobic groups at the periphery yields a refined architecture with lipophilic binding pockets that accommodate defined numbers of biologically relevant guest molecules such as fatty acids or the drug doxorubicin. The size, architecture, and surface textures allow to even penetrate brain endothelial cells that are a major component of the extremely tight blood-brain barrier. In addition, low to no toxicity is observed in in vivo studies using zebrafish embryos. The unique PPD scaffold allows the precise placement of functional groups in a given environment and offers a universal platform for designing drug transporters that closely mimic many features of proteins.

Involved external institutions

Max-Planck-Institut für Polymerforschung (MPI-P) / Max Planck Institute for Polymer Research DE Germany (DE) Universität Ulm DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE)

How to cite

APA:

Stangenberg, R., Wu, Y., Hedrich, J., Kurzbach, D., Wehner, D., Weidinger, G.,... Muellen, K. (2015). A polyphenylene dendrimer drug transporter with precisely positioned amphiphilic surface patches. Advanced Healthcare Materials, 4(3), 377-384. https://doi.org/10.1002/adhm.201400291

MLA:

Stangenberg, Rene, et al. "A polyphenylene dendrimer drug transporter with precisely positioned amphiphilic surface patches." Advanced Healthcare Materials 4.3 (2015): 377-384.

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