Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study

Steinbrenner I, Sekula P, Kotsis F, Von Cube M, Cheng Y, Nadal J, Schmid M, Schneider M, Krane V, Nauck M, Eckardt KU, Schultheiss UT (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Nephrology Dialysis Transplantation Oxford University Press (OUP): Policy B

DOI: 10.1093/ndt/gfac173

Abstract

Background Osteopontin (OPN), synthesized in the thick ascending limb of Henle's loop and in the distal tubule, is involved in the pathogenesis of kidney fibrosis, a hallmark of kidney failure (KF). In a cohort of chronic kidney disease (CKD) patients, we evaluated OPN's association with kidney markers and KF. Methods OPN was measured from baseline serum samples of German Chronic Kidney Disease study participants. Cross-sectional regression models for estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) as well as Cox regression models for all-cause mortality and KF were evaluated to estimate the OPN effect. Additionally, the predictive ability of OPN and time-dependent population-attributable fraction were evaluated. Results Over a median follow-up of 6.5 years, 471 KF events and 629 deaths occurred among 4950 CKD patients. One-unit higher log(OPN) was associated with 5.5 mL/min/1.73 m(2) lower eGFR [95% confidence interval (95% CI) -6.4 to -4.6] and 1% change in OPN with 0.7% higher UACR (estimated effect 0.7, 95% CI 0.6-0.8). Moreover, higher OPN levels were associated with a higher risk of KF [hazard ratio (HR) 1.4, 95% CI 1.2-1.7] and all-cause mortality (HR 1.5, 95% CI 1.3-1.8). After 6 years, 31% of the KF events could be attributed to higher OPN levels (95% CI 3%-56%). Conclusions In this study, higher OPN levels were associated with kidney function markers worsening and a higher risk for adverse outcomes. A larger proportion of KF could be attributed to higher OPN levels, warranting further research on OPN with regards to its role in CKD progression and possible treatment options.

Authors with CRIS profile

Markus Schneider Medizinische Fakultät Kai-Uwe Eckardt Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Albert-Ludwigs-Universität Freiburg DE Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE) Universitätsklinikum Würzburg DE Germany (DE) Universitätsmedizin Greifswald / Universitätsklinikum Greifswald DE Germany (DE)

How to cite

APA:

Steinbrenner, I., Sekula, P., Kotsis, F., Von Cube, M., Cheng, Y., Nadal, J.,... Schultheiss, U.T. (2022). Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study. Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/gfac173

MLA:

Steinbrenner, Inga, et al. "Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study." Nephrology Dialysis Transplantation (2022).

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