Platelet-rich-Plasma in Kombination mit autologer Spongiosa: Eine Alternative bei therapierefraktären Pseudarthrosen?
Hakimi M, Jungbluth P, Thelen S, Linhart W, Flohe S, Windolf J, Wild M, Betsch M (2011)
Publication Type: Journal article
Publication year: 2011
Journal
Book Volume: 114
Pages Range: 998-1006
Journal Issue: 11
DOI: 10.1007/s00113-010-1836-2
Abstract
Background: In addition to a stabile osteosynthesis autologous cancellous bone graft remains an essential therapy option in persistent non-union. Despite this therapy regimen persistent non-union can occasionally occur. The aim of this study was to evaluate the treatment of persistent non-union with a combination of platelet-rich plasma (PRP) and autologous cancellous bone. Material and methods: In this prospective study 17 patients with persistent non-union of long bones were treated by a combination of PRP and autologous iliac crest bone. Inclusion criteria were a minimum of one previously failed cancellous bone transplantation and an atrophic non-union persisting for 6-14 months (mean 9 months). The patients were examined clinically and radiologically at intervals of 3, 6 and 9 months postoperatively. Results: After an average time of 17 months (range 15-23 months) the patients were treated by a combination of PRP and autologous cancellous bone. In all cases the non-union was successfully treated and osseous bridging was found radiologically after an average of 5 months (range 4-7 months) without any complications. Conclusion: The combination of PRP and autologous cancellous bone appears to be a safe and effective method for treatment of persistent non-union. The use of PRP does not result in substantial additional costs. Allergies and graft versus host reactions are not expected because of the autologous origin. © 2010 Springer-Verlag.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Hakimi, M., Jungbluth, P., Thelen, S., Linhart, W., Flohe, S., Windolf, J.,... Betsch, M. (2011). Platelet-rich-Plasma in Kombination mit autologer Spongiosa: Eine Alternative bei therapierefraktären Pseudarthrosen? Unfallchirurg, 114(11), 998-1006. https://dx.doi.org/10.1007/s00113-010-1836-2
MLA:
Hakimi, M., et al. "Platelet-rich-Plasma in Kombination mit autologer Spongiosa: Eine Alternative bei therapierefraktären Pseudarthrosen?" Unfallchirurg 114.11 (2011): 998-1006.
BibTeX: Download