3D semi-quantification of nanoparticle content in tissue on experimental and commercial µCT-scanner

Rahn H, Bayer K, Odenbach S, Lyer S, Alexiou C, Wiekhorst F, Trahms L, Baumann M, Buckwar J, Krause M (2012)

Publication Type: Conference contribution

Publication year: 2012

Publisher: Springer Science and Business Media, LLC

Book Volume: 140

Pages Range: 111-115

Conference Proceedings Title: Springer Proceedings in Physics

Event location: Lubeck, DEU

ISBN: 9783642241321

DOI: 10.1007/978-3-642-24133-8_18

Abstract

X-ray computed tomography is a widely used imaging technique nowadays. Especially in medicine it takes an important role for visualization and diagnostics. Micro-computed tomography (µCT) follows the same principle as conventional medical CT-Scanner. But the objects analyzed are smaller, thus an improvement in spatial resolution down to few micrometers is possible. In the work field of biomedical application of magnetic nanoparticles µCT has been used for the visualization of the nanoparticle accumulations within tumoral regions after magnetic drug targeting. Further on, a calibration procedure has been developed and applied with a µCT-apparatus. The calibration procedure enables a semi-quantification of the nanoparticle content within the tissue samples. The next step stone in visualization process is the observation of the nanoparticle accumulation during the application of magnetic drug targeting in an animal. Thus, we have tested the calibration procedure on a commercial animal scanner. In this paper we compare the semi-quantitative results figured out in two different µCT-equipments.

Authors with CRIS profile

Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery Christoph Alexiou Professur für Nanomedizin

Involved external institutions

Technische Universität Dresden DE Germany (DE) Physikalisch-Technische Bundesanstalt (PTB) DE Germany (DE) Nationales Zentrum für Strahlenforschung in der Onkologie / National Center for Radiation Research in Oncology (NCRO- OncoRay) DE Germany (DE)

How to cite

APA:

Rahn, H., Bayer, K., Odenbach, S., Lyer, S., Alexiou, C., Wiekhorst, F.,... Krause, M. (2012). 3D semi-quantification of nanoparticle content in tissue on experimental and commercial µCT-scanner. In Jorn Borgert, Thorsten M. Buzug (Eds.), Springer Proceedings in Physics (pp. 111-115). Lubeck, DEU: Springer Science and Business Media, LLC.

MLA:

Rahn, Helene, et al. "3D semi-quantification of nanoparticle content in tissue on experimental and commercial µCT-scanner." Proceedings of the 2nd International Workshop on Magnetic Particle Imaging, IWMPI 2012, Lubeck, DEU Ed. Jorn Borgert, Thorsten M. Buzug, Springer Science and Business Media, LLC, 2012. 111-115.

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