Bikker FJ, End C, Ligtenberg AJM, Blaich S, Lyer S, Renner M, Wittig R, Nazmi K, Amerongen AVN, Poustka A, Veerman ECI, Mollenhauer J (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 69
Pages Range: 401-407
Journal Issue: 6
DOI: 10.1007/s00251-017-0982-x
The Scavenger Receptor Cysteine-Rich (SRCR) proteins are an archaic group of proteins characterized by the presence of multiple SRCR domains. They are membrane-bound or secreted proteins, which are generally related to host defense systems in animals. Deleted in Malignant Brain Tumors 1 (DMBT1) is a SRCR protein which is secreted in mucosal fluids and involved in host defense by pathogen binding by its SRCR domains. Genetic polymorphism within DMBT1 leads to DMBT1-alleles giving rise to polypeptides with interindividually different numbers of SRCR domains, ranging from 8 SRCR domains (encoded by 6 kb DMBT1 variant) to 13 SRCR domains (encoded by the 8 kb DMBT1 variant). In the present study, we have investigated whether reduction from 13 to 8 amino-terminal SRCR domains leads to reduction of bacterial binding. The 6 kb variant bound ~20–45% less bacteria compared to the 8 kb variant. These results support the hypothesis that genetic variation in DMBT1 may influence microbial defense.
APA:
Bikker, F.J., End, C., Ligtenberg, A.J.M., Blaich, S., Lyer, S., Renner, M.,... Mollenhauer, J. (2017). The scavenging capacity of DMBT1 is impaired by germline deletions. Immunogenetics, 69(6), 401-407. https://doi.org/10.1007/s00251-017-0982-x
MLA:
Bikker, Floris J., et al. "The scavenging capacity of DMBT1 is impaired by germline deletions." Immunogenetics 69.6 (2017): 401-407.
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