BSA Interaction, Molecular Docking, and Antibacterial Activity of Zinc(II) Complexes Containing the Sterically Demanding Biomimetic N3S2 Ligand: The Effect of Structure Flexibility
Soliman E, Ibrahim MM, El-Khouly ME, El-Mehasseb I, Ramadan AEMM, Mahfouz ME, Shaban SY, van Eldik R (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 27
Journal Issue: 11
DOI: 10.3390/molecules27113543
Abstract
Two zinc(II) complexes, DBZ and DBZH(4), that have (ZnN3S2) cores and differ in the bridging mode of the ligating backbone, effectively bind to BSA. The binding affinity varies as DBZ > DBZH(4) and depends on the ligand structure. At low concentrations, both complexes exhibit dynamic quenching, whereas at higher concentrations they exhibit mixed (static and dynamic) quenching. The energy transfer mechanism from the BSA singlet excited state to DBZ and DBZH(4), is highly likely according to steady-state fluorescence and time-correlated singlet photon counting. Molecular docking was used to support the mode of interaction of the complexes with BSA and showed that DBZ had more energy for binding. Furthermore, antibacterial testing revealed that both complexes were active but to a lesser extent than chloramphenicol. In comparison to DBZH(4), DBZ has higher antibacterial activity, which is consistent with the binding constants, molecular docking, and particle size of adducts. These findings may have an impact on biomedicine.
Authors with CRIS profile
Involved external institutions
Kafr el-Sheikh University
Egypt (EG)
Taif University / جامعة الطائف
Saudi Arabia (SA)
Egypt-Japan University for Science and Technology(E-JUST)
Egypt (EG)
Egypt (EG)
Taif University / جامعة الطائف
Saudi Arabia (SA)
Egypt-Japan University for Science and Technology(E-JUST)
Egypt (EG)
How to cite
APA:
Soliman, E., Ibrahim, M.M., El-Khouly, M.E., El-Mehasseb, I., Ramadan, A.E.-M.M., Mahfouz, M.E.,... van Eldik, R. (2022). BSA Interaction, Molecular Docking, and Antibacterial Activity of Zinc(II) Complexes Containing the Sterically Demanding Biomimetic N3S2 Ligand: The Effect of Structure Flexibility. Molecules, 27(11). https://doi.org/10.3390/molecules27113543
MLA:
Soliman, Eman, et al. "BSA Interaction, Molecular Docking, and Antibacterial Activity of Zinc(II) Complexes Containing the Sterically Demanding Biomimetic N3S2 Ligand: The Effect of Structure Flexibility." Molecules 27.11 (2022).
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