Thurston R, Zantop V, Park KS, Maid H, Seitz A, Heinrich M (2022)
Publication Type: Journal article
Publication year: 2022
DOI: 10.1021/acs.orglett.2c00938
Strategies enabling the pH-dependent conformational switching of amide bonds from trans to cis, and vice versa, are yet limited in the sense that, in a suitable pH range, one rotamer may be stabilized to a large extent while the complementary pH range only leads to a mixture of isomers. By exploiting the effects of steric demand and the interaction of the amide carbonyl with a positive charge, we herein present the first examples for reversible pH-dependent switching from full trans to full cis.
APA:
Thurston, R., Zantop, V., Park, K.S., Maid, H., Seitz, A., & Heinrich, M. (2022). PH-Dependent Conformational Switching of Amide Bonds from Full trans to Full cis and Vice Versa. Organic Letters. https://doi.org/10.1021/acs.orglett.2c00938
MLA:
Thurston, Ryan, et al. "PH-Dependent Conformational Switching of Amide Bonds from Full trans to Full cis and Vice Versa." Organic Letters (2022).
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