Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer.
Schwartz C, O'Grady K, Lavelle EC, Fallon PG (2016)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2016
Journal
Book Volume: 46
Pages Range: 1091-100
Journal Issue: 5
Abstract
Interleukin (IL)-33, a member of the IL-1 family, was originally described in 2005 as a potent initiator of type 2 immunity found during allergic inflammation and parasitic infections. IL-33 has been shown to play important and potent roles bridging innate and adaptive immunity in the regulation of tissue homeostasis, injury, and repair. Recent discoveries have extended the range of functions for IL-33 beyond type 2 conditions and its role as an alarmin at barrier sites, with emerging central roles for IL-33 in T-cell regulation, obesity, viral and tumor immunity. Here, we review the recent advances on how IL-33 activity is regulated, its immunomodulatory properties on innate and adaptive cells, and the newly discovered roles of IL-33 in obesity, intestinal inflammation, and tumorigenesis.
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Ireland (IE)How to cite
APA:
Schwartz, C., O'Grady, K., Lavelle, E.C., & Fallon, P.G. (2016). Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer. European Journal of Immunology, 46(5), 1091-100. https://doi.org/10.1002/eji.201545780
MLA:
Schwartz, Christian, et al. "Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer." European Journal of Immunology 46.5 (2016): 1091-100.
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