ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.

Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR, Mckenzie ANJ, Fallon PG (2017)

Publication Status: Published

Publication Type: Journal article

Publication year: 2017

Journal

Journal of Experimental Medicine Rockefeller University Press

Book Volume: 214

Pages Range: 2507-2521

Journal Issue: 9

DOI: 10.1084/jem.20170051

Abstract

Our results identify a novel PD-L1-controlled mechanism for type 2 polarization, with ILC2s mediating an innate checkpoint to control adaptive T helper responses, which has important implications for the treatment of type 2 inflammation.

Authors with CRIS profile

Christian Schwartz Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene

Involved external institutions

Trinity College Dublin IE Ireland (IE) Medical Research Council GB United Kingdom (GB) Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE)

How to cite

APA:

Schwartz, C., Khan, A.R., Floudas, A., Saunders, S.P., Hams, E., Rodewald, H.-R.,... Fallon, P.G. (2017). ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control. Journal of Experimental Medicine, 214(9), 2507-2521. https://doi.org/10.1084/jem.20170051

MLA:

Schwartz, Christian, et al. "ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control." Journal of Experimental Medicine 214.9 (2017): 2507-2521.

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