Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, Mckenzie AN, Walsh PT, Fallon PG (2017)
Publication Status: Published
Publication Type: Journal article
Publication year: 2017
Book Volume: 199
Pages Range: 707-717
Journal Issue: 2
mice was dependent on TSLP, but not the other alarmins IL-25 and IL-33. The associated skin inflammation was mediated by IL-5-expressing pathogenic effector Th2 cells and was independent of TCRγδ T cells and IL-22. An absence of IL-17RA in nonhematopoietic cells, but not in the hematopoietic cells, was required for the development of spontaneous skin inflammation. Skin microbiome dysbiosis developed in the absence of IL-17RA, with antibiotic intervention resulting in significant amelioration of skin inflammation and reductions in skin-infiltrating pathogenic effector Th2 cells and TSLP. This study describes a previously unappreciated protective role for IL-17RA signaling in regulation of the skin barrier and maintenance of skin immune homeostasis.
APA:
Floudas, A., Saunders, S.P., Moran, T., Schwartz, C., Hams, E., Fitzgerald, D.C.,... Fallon, P.G. (2017). IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation. Journal of Immunology, 199(2), 707-717. https://doi.org/10.4049/jimmunol.1602185
MLA:
Floudas, Achilleas, et al. "IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation." Journal of Immunology 199.2 (2017): 707-717.
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