Helminth Modulation of Lung Inflammation.

Schwartz C, Hams E, Fallon PG (2018)

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2018

Journal

Trends in Parasitology Elsevier

Book Volume: 34

Pages Range: 388-403

Journal Issue: 5

DOI: 10.1016/j.pt.2017.12.007

Abstract

Parasitic helminths must establish chronic infections to complete their life cycle and therefore are potent modulators of multiple facets of host physiology. Parasitic helminths have coevolved with humans to become arguably master selectors of our immune system, whereby they have impacted on the selection of genes with beneficial mutations for both host and parasite. While helminth infections of humans are a significant health burden, studies have shown that helminths or helminth products can alter susceptibility to unrelated infectious or inflammatory diseases. This has generated interest in the use of helminth infections or molecules as therapeutics. In this review, we focus on the impact of helminth infections on pulmonary immunity, especially with regard to homeostatic lung function, pulmonary viral and bacterial (co)infections, and asthma.

Authors with CRIS profile

Christian Schwartz Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene

Involved external institutions

Trinity College Dublin

Ireland (IE)

How to cite

APA:

Schwartz, C., Hams, E., & Fallon, P.G. (2018). Helminth Modulation of Lung Inflammation. Trends in Parasitology, 34(5), 388-403. https://doi.org/10.1016/j.pt.2017.12.007

MLA:

Schwartz, Christian, Emily Hams, and Padraic G. Fallon. "Helminth Modulation of Lung Inflammation." Trends in Parasitology 34.5 (2018): 388-403.

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