Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.

Minutti CM, Drube S, Blair N, Schwartz C, Mccrae JC, Mckenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM (2017)

Publication Status: Published

Publication Type: Journal article

Publication year: 2017

Journal

Immunity Elsevier

Book Volume: 47

Pages Range: 710-722.e6

Journal Issue: 4

DOI: 10.1016/j.immuni.2017.09.013

Abstract

Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR. This shared signaling complex allowed IL-33 to induce the EGFR-mediated activation of the MAP-kinase signaling pathway and consequently the expression of IL-13. Lack of EGFR expression on T cells abrogated IL-13 expression in infected tissues and impaired host resistance. EGFR expression on Th2 cells was TCR-signaling dependent, and therefore, our data reveal a mechanism by which antigen presentation controls the innate effector function of Th2 cells at the site of inflammation.

Authors with CRIS profile

Christian Schwartz Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene

Involved external institutions

University of Edinburgh GB United Kingdom (GB) Universitätsklinikum Jena DE Germany (DE) Universiteit Utrecht (UU) / Utrecht University NL Netherlands (NL) Medical Research Council (MRC) Prion Unit GB United Kingdom (GB) University Medical Centre Utrecht (UMC Utrecht) NL Netherlands (NL) Medizinische Universität Wien AT Austria (AT) Trinity College Dublin IE Ireland (IE)

How to cite

APA:

Minutti, C.M., Drube, S., Blair, N., Schwartz, C., Mccrae, J.C., Mckenzie, A.N.,... Zaiss, D.M. (2017). Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion. Immunity, 47(4), 710-722.e6. https://doi.org/10.1016/j.immuni.2017.09.013

MLA:

Minutti, Carlos M., et al. "Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion." Immunity 47.4 (2017): 710-722.e6.

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