Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease.

Burgmaier K, Kunzmann K, Ariceta G, Bergmann C, Buescher AK, Burgmaier M, Dursun I, Duzova A, Eid L, Erger F, Feldkoetter M, Galiano M, Gessner M, Goebel H, Gokce I, Haffner D, Hooman N, Hoppe B, Jankauskiene A, Klaus G, Koenig J, Litwin M, Massella L, Mekahli D, Melek E, Mir S, Pape L, Prikhodina L, Ranchin B, Schild R, Seeman T, Sever L, Shroff R, Soliman NA, Stabouli S, Stanczyk M, Tabel Y, Taranta-Janusz K, Testa S, Thumfart J, Topaloglu R, Weber LT, Wicher D, Wuehl E, Wygoda S, Yilmaz A, Zachwieja K, Zagozdzon I, Zerres K, Doetsch J, Schaefer F, Liebau MC (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 199

Pages Range: 22-28.e6

DOI: 10.1016/j.jpeds.2018.03.052

Abstract

OBJECTIVE: To identify prenatal, perinatal, and postnatal risk factors for dialysis within the first year of life in children with autosomal recessive polycystic kidney disease (ARPKD) as a basis for parental counseling after prenatal and perinatal diagnosis. STUDY DESIGN: A dataset comprising 385 patients from the ARegPKD international registry study was analyzed for potential risk markers for dialysis during the first year of life. RESULTS: Thirty-six out of 385 children (9.4%) commenced dialysis in the first year of life. According to multivariable Cox regression analysis, the presence of oligohydramnios or anhydramnios, prenatal kidney enlargement, a low Apgar score, and the need for postnatal breathing support were independently associated with an increased hazard ratio for requiring dialysis within the first year of life. The increased risk associated with Apgar score and perinatal assisted breathing was time-dependent and vanished after 5 and 8 months of life, respectively. The predicted probabilities for early dialysis varied from 1.5% (95% CI, 0.5%-4.1%) for patients with ARPKD with no prenatal sonographic abnormalities to 32.3% (95% CI, 22.2%-44.5%) in cases of documented oligohydramnios or anhydramnios, renal cysts, and enlarged kidneys. CONCLUSIONS: This study, which identified risk factors associated with onset of dialysis in ARPKD in the first year of life, may be helpful in prenatal parental counseling in cases of suspected ARPKD.

Involved external institutions

Ruprecht-Karls-Universität Heidelberg Germany (DE) İnönü University Turkey (TR) Hacettepe University Turkey (TR) Universitätsklinikum Köln Germany (DE) Children's Memorial Health Institute / Instytut "Pomnik - Centrum Zdrowia Dziecka" Poland (PL) Universitätsklinikum Tübingen Germany (DE) Marmara University Turkey (TR) Çukurova Üniversitesi Turkey (TR) Klinikum St. Georg Germany (DE) Universitätsklinikum Bonn Germany (DE) University of Białystok Poland (PL) Bioscientia Healthcare Group Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Universitätsklinikum Aachen (UKA) Germany (DE) Universitätsklinikum Essen Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Jagiellonian University / Uniwersytet Jagielloński (UJ) Poland (PL) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Germany (DE) Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico Italy (IT) Istanbul University / İstanbul Üniversitesi Turkey (TR) Universitätsklinikum Münster Germany (DE) Aristotle University of Thessaloniki Greece (GR) Pirogov Russian National Research Medical University (RSMU / RNRMU) Russian Federation (RU) Erciyes University / Erciyes Üniversitesi Turkey (TR) Ospedale Pediatrico Bambino Gesu Italy (IT) Ege University / Ege Üniversitesi Turkey (TR) Charité - Universitätsmedizin Berlin Germany (DE) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron Spain (ES) Iran University of Medical Sciences (IUMS) / دانشگاه علوم پزشکی ایران Iran, Islamic Republic of (IR) Dubai Hospital United Arab Emirates (AE) Cairo University Egypt (EG) Hospices Civils de Lyon (CHU) France (FR) Great Ormond Street Hospital (GOSH) United Kingdom (GB) Instytut Centrum Zdrowia Matki Polki w Łodzi (ICZMP) / Polish Mother’s Memorial Hospital Research Institute Poland (PL) Medical University Gdansk / Gdański Uniwersytet Medyczny Poland (PL)

How to cite

APA:

Burgmaier, K., Kunzmann, K., Ariceta, G., Bergmann, C., Buescher, A.K., Burgmaier, M.,... Liebau, M.C. (2018). Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease. Journal of Pediatrics, 199, 22-28.e6. https://doi.org/10.1016/j.jpeds.2018.03.052

MLA:

Burgmaier, Kathrin, et al. "Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease." Journal of Pediatrics 199 (2018): 22-28.e6.

BibTeX: Download