EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees†.

Horwich A, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Van Der Kwast T, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis , Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Comperat E, Crabb S, Culine S, De Bari B, De Blok W, De Visschere PJL, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne , Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmueller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez , Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo , Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinos E, Logager , Lorch A, Loriot Y, Meijer R, Carmen Mir M, Moschini M, Mostafid H, Mueller AC, Mueller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, Oyen WJG, Pacheco-Figueiredo L, Pappot H, Patel M, Pieters BR, Plass K, Remzi M, Retz M, Richenberg J, Rink M, Roghmann F, Rosenberg JE, Roupret M, Rouviere O, Salembier C, Salminen A, Sargos P, Sengupta S, Sherif A, Smeenk RJ, Smits A, Stenzl A, Thalmann GN, Tombal B, Turkbey B, Lauridsen SV, Valdagni R, Van Der Heijden AG, Van Poppel H, Vartolomei MD, Veskimae E, Vilaseca A, Vives Rivera FA, Wiegel T, Wiklund P, Williams A, Zigeuner R, Witjes JA (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 30

Pages Range: 1697-1727

Journal Issue: 11

DOI: 10.1093/annonc/mdz296

Abstract

BACKGROUND: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. OBJECTIVE: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. DESIGN: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts before voting during a consensus conference. SETTING: Online Delphi survey and consensus conference. PARTICIPANTS: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus). RESULTS AND LIMITATIONS: Overall, 116 statements were included in the Delphi survey. Of these, 33 (28%) statements achieved level 1 consensus and 49 (42%) statements achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease and the evolving role of checkpoint inhibitor therapy in metastatic disease. CONCLUSIONS: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time where further evidence is available to guide our approach.

Authors with CRIS profile

Involved external institutions

University of Glasgow United Kingdom (GB) NHS Royal Surrey NHS Foundation Trust United Kingdom (GB) Kliniken Essen-Mitte Germany (DE) University of Texas MD Anderson Cancer Center United States (USA) (US) Centre Georges François Leclerc (UNICANCER) France (FR) Kantonsspital Graubünden Switzerland (CH) Herlev Hospital Denmark (DK) Hospital Universitario La Paz Spain (ES) Universitat de Barcelona (UB) / University of Barcelona Spain (ES) Istituto Clinico Humanitas Italy (IT) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona Spain (ES) University of Utah United States (USA) (US) University of Manchester United Kingdom (GB) University of British Columbia Canada (CA) Medizinische Universität Wien Austria (AT) University of Amsterdam Netherlands (NL) National and Kapodistrian University of Athens Greece (GR) The Institute of Cancer Research (ICR) United Kingdom (GB) IMIM: Institut Hospital del Mar d'Investigacions Mèdiques Spain (ES) Royal Free Hospital United Kingdom (GB) University Hospitals Birmingham NHS Foundation Trust United Kingdom (GB) University of Grenoble Alpes (UGA) / Université de Grenoble France (FR) University of California, San Diego United States (USA) (US) Julius-Maximilians-Universität Würzburg Germany (DE) Universität Regensburg Germany (DE) Radboud University Nijmegen Netherlands (NL) University Hospital Ghent Belgium (BE) Valencia Oncology Institute Foundation / Fundación Instituto Valenciano de Oncología / Fundació Institut Valencià d’Oncologia (IVO) Spain (ES) University of Southampton United Kingdom (GB) University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL) University of Western Australia (UWA) Australia (AU) Universitätsklinikum Essen Germany (DE) Assistance Publique-Hôpitaux de Paris (AP-HP) France (FR) Hôpital Tenon France (FR) Erasmus University Medical Center (MC) Netherlands (NL) Hospital Universitario 12 de Octubre Spain (ES) Umeå University Sweden (SE) Fondazione IRCCS: Istituto Nazionale dei Tumori Italy (IT) Akershus University Hospital / Akershus universitetssykehus (Ahus) Norway (NO) Luzerner Kantonsspital (LUKS) Switzerland (CH) Universitätsspital Zürich (USZ) Switzerland (CH) Eberhard Karls Universität Tübingen Germany (DE) Leiden University Netherlands (NL) Technische Universität München (TUM) Germany (DE) Università degli studi di Milano Italy (IT) Hospices Civils de Lyon (CHU) France (FR) University of Sydney (USYD) Australia (AU) Hospital de São João / Saint John Hospital Portugal (PT) Inselspital, Universitätsspital Bern Switzerland (CH) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS) Finland (FI) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne France (FR) Royal Sussex County Hospital United Kingdom (GB) University of Oxford United Kingdom (GB) Memorial Sloan Kettering Cancer Center United States (USA) (US) University of Aberdeen United Kingdom (GB) Tampere University Hospital / Tampereen yliopistollinen sairaala (TAYS) Finland (FI) Copenhagen University Hospital Denmark (DK) National Cancer Institute (NCI) United States (USA) (US) Hôpital Bichat-Claude-Bernard (CHU, APHP) France (FR) European Association of Urology Netherlands (NL) Canisius-Wilhelmina Ziekenhuis Netherlands (NL) University of Turin / Università degli Studi di Torino (UNITO) Italy (IT) Auckland City Hospital New Zealand (NZ) Cornell University United States (USA) (US) University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud France (FR) University College London (UCL) United Kingdom (GB) Versailles Saint-Quentin-en-Yvelines University / Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) France (FR) Institut Bergonié France (FR) Aberdeen Royal Infirmary (ARI) United Kingdom (GB) Icahn School of Medicine at Mount Sinai United States (USA) (US) The University of Melbourne Australia (AU) Centre hospitalier régional et universitaire de Besançon (CHRU Besancon) France (FR) Universitätsklinikum Ulm Germany (DE) Monash University Australia (AU) University of Bologna / Università di Bologna Italy (IT) University of Leeds United Kingdom (GB) "Saint John" Emergency Clinical Hospital Romania (RO) Hospital Universitario Fundación Alcorcón (HUFA) Spain (ES) Institut Gustave-Roussy France (FR) University of Groningen / Rijksuniversiteit Groningen Netherlands (NL) Sørlandet Hospital Kristiansand Norway (NO)

How to cite

APA:

Horwich, A., Babjuk, M., Bellmunt, J., Bruins, H.M., De Reijke, T.M., De Santis, M.,... Witjes, J.A. (2019). EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees†. Annals of Oncology, 30(11), 1697-1727. https://doi.org/10.1093/annonc/mdz296

MLA:

Horwich, A., et al. "EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees†." Annals of Oncology 30.11 (2019): 1697-1727.

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