Assessment of tumor development and wound healing using endoscopic techniques in mice

Günther C, Neurath M, Waldner M, Neufert C, Wirtz S, Becker C (2010)

Publication Language: English

Publication Status: Published

Publication Type: Journal article

Publication year: 2010

Journal

Gastroenterology Elsevier

Book Volume: 139

Pages Range: 1837-1843.e1

Journal Issue: 6

DOI: 10.1053/j.gastro.2010.10.007

Abstract

Mouse models of intestinal inflammation and colon cancer are valuable tools to gain insights into the pathogenesis of the corresponding human diseases. Recently, in vivo mouse endoscopy has been developed, allowing not only the high-resolution monitoring and scoring of experimental disease development, but also enables the investigator to perform manipulations, including local injection of reagents or the taking of biopsies for molecular and histopathologic analyses. Chromoendoscopic staining with methylene blue enables visualization of the crypt structure and allows discrimination between inflammatory and neoplastic changes. The development of endoscopic techniques in live mice opened new options for the investigation of disease mechanisms in the gut and for the preclinical testing of potential therapeutic effects of drug candidates. Finally, mouse endoscopy can help to reduce animal numbers needed to gain significant experimental data.

Authors with CRIS profile

Claudia Günther Professur für Gastrointestinale Pathophysiologie Markus Neurath Lehrstuhl für Innere Medizin I Maximilian Waldner Professur für Funktionelle Bildgebung in der Medizin Clemens Neufert Medizinische Fakultät Stefan Wirtz Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Christoph Becker Professur für Molekulare Gastroenterologie

How to cite

APA:

Günther, C., Neurath, M., Waldner, M., Neufert, C., Wirtz, S., & Becker, C. (2010). Assessment of tumor development and wound healing using endoscopic techniques in mice. Gastroenterology, 139(6), 1837-1843.e1. https://doi.org/10.1053/j.gastro.2010.10.007

MLA:

Günther, Claudia, et al. "Assessment of tumor development and wound healing using endoscopic techniques in mice." Gastroenterology 139.6 (2010): 1837-1843.e1.

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