Balks J, Mueller A, Herberg U, Geipel A, Gembruch U, Schroeder L, Breuer J, Weidenbach M, Berg C, Kipfmueller F, Dewald O (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 225
Pages Range: 432-440
Journal Issue: 5
DOI: 10.1055/a-1392-1460
The mortality of patients with isolated congenital diaphragmatic hernia (CDH) in specialized centers is 20-40 %. The main factors influencing the outcome are the underlying pulmonary hypoplasia, the resulting pulmonary hypertension and the presence of other malformations. Concomitant malformations such as congenital heart defects occur in around 18 % of all neonates with a diaphragmatic hernia. Serious congenital heart defects such as hypoplastic left heart syndrome occur in approximately 8 % of cases. In a retrospective analysis of the patient collective of our hospital between 01/2012 and 12/2018, the prenatal and postnatal management as well as the outcome of newborns with a combination of congenital heart defects and diaphragmatic hernias were examined. During the study period, 156 newborns with diaphragmatic hernias were treated at our institution. In 10 patients (6.4 %) there was also a severe, and in 11 patients (7.1 %) a moderate heart defect. 6/21 patients died during their hospital stay, 3 of them on the first day of life. There was a significantly lower mortality in patients with diaphragmatic hernia and moderate heart defects compared to severe heart defects (9 vs. 50 %). The mortality in children with a univentricular heart was particularly high. Despite a significantly reduced prognosis for the combination of congenital heart defects and diaphragmatic hernia, generally a poor prognosis does not have to be expected. A curative approach can be achieved in specialized centers.
APA:
Balks, J., Mueller, A., Herberg, U., Geipel, A., Gembruch, U., Schroeder, L.,... Dewald, O. (2021). Therapy and Outcome of Neonates with Congenital Diaphragmatic Hernia and Congenital Heart Defects Therapie und Outcome von Neugeborenen mit kongenitaler Zwerchfellhernie und angeborenen Herzfehlern. Zeitschrift für Geburtshilfe und Neonatologie, 225(5), 432-440. https://doi.org/10.1055/a-1392-1460
MLA:
Balks, Julian, et al. "Therapy and Outcome of Neonates with Congenital Diaphragmatic Hernia and Congenital Heart Defects Therapie und Outcome von Neugeborenen mit kongenitaler Zwerchfellhernie und angeborenen Herzfehlern." Zeitschrift für Geburtshilfe und Neonatologie 225.5 (2021): 432-440.
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