ASSOCIATIONS BETWEEN PREDICTED AND ACTUAL STRUCTURAL PROGRESSION IN THE APPROACH COHORT
Jansen M, Wirth W, Roemer F, Bacardit J, Van Helvoort EM, Marijnissen AC, Kloppenburg M, Blanco FJ, Haugen IK, Berenbaum F, Lafeber FP, Welsing PM, Mastbergen SC (2022)
Publication Type: Conference contribution
Publication year: 2022
Journal
Publisher: ELSEVIER SCI LTD
City/Town: OXFORD
Pages Range: S283-S284
Conference Proceedings Title: OSTEOARTHRITIS AND CARTILAGE
DOI: 10.1016/j.joca.2022.02.381
Abstract
Since osteoarthritis (OA) is a heterogeneous disease in terms of progression, many trials include patients showing barely or no progression, particularly in early stages of the disease. In the APPROACH study, machine learning models were trained to predict structural and pain progression of individual participants before inclusion. Predicted progression was differentiated into a structural (S) and pain (P) progression score, where the score (range 0-1) reflected the likelihood of a participant being a progressor. Structural progression was defined as a decrease in minimum joint space width (JSW) of at least 0.3mm/year. Only participants with the estimated highest 75% combined (P+S) score after screening were included. The purpose of the current study was to evaluate the associations between the predicted and actual structural progression according to different parameters over two years.
Authors with CRIS profile
Involved external institutions
Newcastle University
United Kingdom (GB)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Diakonhjemmet Hospital
Norway (NO)
University of A Coruña / Universidade da Coruña
Spain (ES)
Paracelsus Medizinische Privatuniversität
Austria (AT)
University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne
France (FR)
Leiden University Medical Center
Netherlands (NL)
United Kingdom (GB)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Diakonhjemmet Hospital
Norway (NO)
University of A Coruña / Universidade da Coruña
Spain (ES)
Paracelsus Medizinische Privatuniversität
Austria (AT)
University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne
France (FR)
Leiden University Medical Center
Netherlands (NL)
How to cite
APA:
Jansen, M., Wirth, W., Roemer, F., Bacardit, J., Van Helvoort, E.M., Marijnissen, A.C.,... Mastbergen, S.C. (2022). ASSOCIATIONS BETWEEN PREDICTED AND ACTUAL STRUCTURAL PROGRESSION IN THE APPROACH COHORT. In OSTEOARTHRITIS AND CARTILAGE (pp. S283-S284). OXFORD: ELSEVIER SCI LTD.
MLA:
Jansen, M., et al. "ASSOCIATIONS BETWEEN PREDICTED AND ACTUAL STRUCTURAL PROGRESSION IN THE APPROACH COHORT." Proceedings of the OSTEOARTHRITIS AND CARTILAGE OXFORD: ELSEVIER SCI LTD, 2022. S283-S284.
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