Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives

Banjarnahor S, König J, Maas R (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Amino Acids Springer Verlag (Germany)

DOI: 10.1007/s00726-022-03156-2

Abstract

The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of l-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of l-arginine, l-homoarginine, and asymmetric dimethylarginine (ADMA). Twenty-three (20%) of the tested substances showed weak inhibitory or stimulatory effects, but only verapamil showed consistent inhibitory effects on CAT1-mediated transport of all tested substrates.

Authors with CRIS profile

Sofna Banjarnahor Professur für Arzneimitteltherapiesicherheit und Klinische Pharmakologie Jörg König Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie Renke Maas Professur für Arzneimitteltherapiesicherheit und Klinische Pharmakologie

How to cite

APA:

Banjarnahor, S., König, J., & Maas, R. (2022). Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives. Amino Acids. https://doi.org/10.1007/s00726-022-03156-2

MLA:

Banjarnahor, Sofna, Jörg König, and Renke Maas. "Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives." Amino Acids (2022).

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