Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes

Horatz K, Ditte K, Prenveille T, Zhang KN, Jehnichen D, Kiriy A, Voit B, Lissel F (2019)

Publication Type: Journal article

Publication year: 2019

Journal

ChemPlusChem Wiley

Book Volume: 84

Pages Range: 1338-1345

Journal Issue: 9

DOI: 10.1002/cplu.201900203

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) usually employs highly crystalline small-molecule matrices, and the analyte is interpreted as being co-crystallized with the matrix. We recently showed that semi-crystalline polymers are efficient matrices for the detection of low-molecular-weight compounds (LMWCs) in MALDI MS and MALDI MS Imaging, and are dual-mode, i. e., enabling both positive and negative modes. The matrix performances of two fluorene/napthalene diimide co-polymers P(TNDIT-Fl(C4C2)) and P(TNDIT-Fl(C10C8)) were investigated and compared. Both are fully amorphous according to XRD measurements, show high relative absorption values at the wavelength of common MALDI lasers (λNd:YAG=355 nm: C4C2=73 %; C10C8=67 %), and are solution processable. As matrices, they are dual-mode, and enable the detection of LMWCs while being mostly MALDI-silent. Compared with semicrystalline polymer matrices, the amorphous matrices give similar or better signal intensities, thus indicating that analyte inclusion takes place in the amorphous part of the polymer matrix.

Involved external institutions

Leibniz-Institut für Polymerforschung Dresden e. V. DE Germany (DE)

How to cite

APA:

Horatz, K., Ditte, K., Prenveille, T., Zhang, K.-N., Jehnichen, D., Kiriy, A.,... Lissel, F. (2019). Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes. ChemPlusChem, 84(9), 1338-1345. https://doi.org/10.1002/cplu.201900203

MLA:

Horatz, Kilian, et al. "Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes." ChemPlusChem 84.9 (2019): 1338-1345.

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