Functional Cellular Mimics for the Spatiotemporal Control of Multiple Enzymatic Cascade Reactions
Liu X, Formanek P, Voit B, Appelhans D (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 56
Pages Range: 16233-16238
Journal Issue: 51
Abstract
Next-generation therapeutic approaches are expected to rely on the engineering of biomimetic cellular systems that can mimic specific cellular functions. Herein, we demonstrate a highly effective route for constructing structural and functional eukaryotic cell mimics by loading pH-sensitive polymersomes as membrane-associated and free-floating organelle mimics inside the multifunctional cell membrane. Metabolism mimicry has been validated by performing successive enzymatic cascade reactions spatially separated at specific sites of cell mimics in the presence and absence of extracellular organelle mimics. These enzymatic reactions take place in a highly controllable, reproducible, efficient, and successive manner. Our biomimetic approach to material design for establishing functional principles brings considerable enrichment to the fields of biomedicine, biocatalysis, biotechnology, and systems biology.
Involved external institutions
Germany (DE)How to cite
APA:
Liu, X., Formanek, P., Voit, B., & Appelhans, D. (2017). Functional Cellular Mimics for the Spatiotemporal Control of Multiple Enzymatic Cascade Reactions. Angewandte Chemie International Edition, 56(51), 16233-16238. https://doi.org/10.1002/anie.201708826
MLA:
Liu, Xiaoling, et al. "Functional Cellular Mimics for the Spatiotemporal Control of Multiple Enzymatic Cascade Reactions." Angewandte Chemie International Edition 56.51 (2017): 16233-16238.
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