Embedment of Quantum Dots and Biomolecules in a Dipeptide Hydrogel Formed In Situ Using Microfluidics

Li Y, Maennel MJ, Hauck N, Patel HP, Auernhammer GK, Chae S, Fery A, Li J, Thiele J (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Angewandte Chemie International Edition Wiley

Book Volume: 60

Pages Range: 6724-6732

Journal Issue: 12

DOI: 10.1002/anie.202015340

Abstract

As low-molecular-weight hydrogelators, dipeptide hydrogel materials are suited for embedding multiple organic molecules and inorganic nanoparticles. Herein, a simple but precisely controllable method is presented that enables the fabrication of dipeptide-based hydrogels by supramolecular assembly inside microfluidic channels. Water-soluble quantum dots (QDs) as well as premixed porphyrins and a dipeptide in dimethyl sulfoxide (DMSO) were injected into a Y-shaped microfluidic junction. At the DMSO/water interface, the confined fabrication of a dipeptide-based hydrogel was initiated. Thereafter, the as-formed hydrogel flowed along a meandering microchannel in a continuous fashion, gradually completing gelation and QD entrapment. In contrast to hydrogelation in conventional test tubes, microfluidically controlled hydrogelation led to a tailored dipeptide hydrogel regarding material morphology and nanoparticle distribution.

Involved external institutions

Leibniz-Institut für Polymerforschung Dresden e. V. DE Germany (DE) Chinese Academy of Sciences (CAS) / 中国科学院 CN China (CN)

How to cite

APA:

Li, Y., Maennel, M.J., Hauck, N., Patel, H.P., Auernhammer, G.K., Chae, S.,... Thiele, J. (2021). Embedment of Quantum Dots and Biomolecules in a Dipeptide Hydrogel Formed In Situ Using Microfluidics. Angewandte Chemie International Edition, 60(12), 6724-6732. https://doi.org/10.1002/anie.202015340

MLA:

Li, Yue, et al. "Embedment of Quantum Dots and Biomolecules in a Dipeptide Hydrogel Formed In Situ Using Microfluidics." Angewandte Chemie International Edition 60.12 (2021): 6724-6732.

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