Polymerizing Like Mussels Do: Toward Synthetic Mussel Foot Proteins and Resistant Glues

Horsch J, Wilke P, Pretzler M, Seuss M, Melnyk I, Remmler D, Fery A, Rompel A, Boerner HG (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Angewandte Chemie International Edition Wiley

Book Volume: 57

Pages Range: 15728-15732

Journal Issue: 48

DOI: 10.1002/anie.201809587

Abstract

A novel strategy to generate adhesive protein analogues by enzyme-induced polymerization of peptides is reported. Peptide polymerization relies on tyrosinase oxidation of tyrosine residues to Dopaquinones, which rapidly form cysteinyldopa-moieties with free thiols from cysteine residues, thereby linking unimers and generating adhesive polymers. The resulting artificial protein analogues show strong adsorption to different surfaces, even resisting hypersaline conditions. Remarkable adhesion energies of up to 10.9 mJ m−2 are found in single adhesion events and average values are superior to those reported for mussel foot proteins that constitute the gluing interfaces.

Involved external institutions

Humboldt-Universität zu Berlin DE Germany (DE) Universität Wien / University of Vienna AT Austria (AT) Leibniz-Institut für Polymerforschung Dresden e. V. DE Germany (DE)

How to cite

APA:

Horsch, J., Wilke, P., Pretzler, M., Seuss, M., Melnyk, I., Remmler, D.,... Boerner, H.G. (2018). Polymerizing Like Mussels Do: Toward Synthetic Mussel Foot Proteins and Resistant Glues. Angewandte Chemie International Edition, 57(48), 15728-15732. https://doi.org/10.1002/anie.201809587

MLA:

Horsch, Justus, et al. "Polymerizing Like Mussels Do: Toward Synthetic Mussel Foot Proteins and Resistant Glues." Angewandte Chemie International Edition 57.48 (2018): 15728-15732.

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