Human α-thrombin detection platform using aptamers on a silicon nanowire field-effect transistor

Römhildt L, Zörgiebel F, Ibarlucea B, Vahdatzadeh M, Baraban L, Cuniberti G, Pregl S, Weber WM, Mikolajick T, Opitz J (2017)

Publication Type: Conference contribution

Publication year: 2017

Publisher: Institute of Electrical and Electronics Engineers Inc.

Book Volume: 2017-January

Pages Range: 1-4

Conference Proceedings Title: 2017 27th International Symposium on Power and Timing Modeling, Optimization and Simulation, PATMOS 2017

Event location: Thessaloniki, GRC

ISBN: 9781509064625

DOI: 10.1109/PATMOS.2017.8106958

Abstract

We present a silicon nanowire-based field-effect transistor biosensor with Schottky barriers for highly specific and sensitive human α-thrombin detection. The active sensor area is decorated with thrombin-binding aptamers as receptor molecules. Each sensor chip is integrated into a microfluidic device for flow-through measurements. Instantaneous detection is provided by real-time monitoring of FET transfer curves. With this approach, thrombin concentrations between 200 pM and 200 nM are detected in a label-free, real-time manner, covering a wide dynamic range and enabling to distinguish between healthy and pathological levels. The development of simple, miniaturized devices for blood protein detection is highly interesting for medical diagnostics.

Involved external institutions

Technische Universität Dresden DE Germany (DE) Fraunhofer-Institut für Keramische Technologien und Systeme (IKTS) DE Germany (DE)

How to cite

APA:

Römhildt, L., Zörgiebel, F., Ibarlucea, B., Vahdatzadeh, M., Baraban, L., Cuniberti, G.,... Opitz, J. (2017). Human α-thrombin detection platform using aptamers on a silicon nanowire field-effect transistor. In 2017 27th International Symposium on Power and Timing Modeling, Optimization and Simulation, PATMOS 2017 (pp. 1-4). Thessaloniki, GRC: Institute of Electrical and Electronics Engineers Inc..

MLA:

Römhildt, Lotta, et al. "Human α-thrombin detection platform using aptamers on a silicon nanowire field-effect transistor." Proceedings of the 27th International Symposium on Power and Timing Modeling, Optimization and Simulation, PATMOS 2017, Thessaloniki, GRC Institute of Electrical and Electronics Engineers Inc., 2017. 1-4.

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