Metal-Organic Framework/Graphene Quantum Dot Nanoparticles Used for Synergistic Chemo- and Photothermal Therapy

Tian Z, Yao X, Ma K, Niu X, Grothe J, Xu Q, Liu L, Kaskel S, Zhu Y (2017)

Publication Type: Journal article

Publication year: 2017

Journal

ACS Omega American Chemical Society: Open Access Titles / American Chemical Society

Book Volume: 2

Pages Range: 1249-1258

Journal Issue: 3

DOI: 10.1021/acsomega.6b00385

Abstract

In this study, a simple one-pot method was used to prepare a multifunctional platform for synergistic chemo- and photothermal therapy, which is composed of zeolitic imidazolate framework-8 (ZIF-8) as drug nanocarriers and the embedded graphene quantum dots (GQDs) as local photothermal seeds. The structure, drug release behavior, photothermal effect, and synergistic therapeutic efficiency of the ZIF-8/GQD nanoparticles were systematically investigated. Using doxorubicin (DOX) as a model anticancer drug, the results showed that monodisperse ZIF-8/GQD nanoparticles with a particle size of 50-100 nm could encapsulate DOX during the synthesis procedure and trigger DOX release under acidic conditions. The DOX-loaded ZIF-8/GQD nanoparticles could efficiently convert near-infrared (NIR) irradiation into heat and thereby increase the temperature. More importantly, with breast cancer 4T1 cells as a model cellular system, the results indicated that the combined chemo- and photothermal therapy with DOX-ZIF-8/GQD nanoparticles exhibited a significant synergistic effect, resulting in a higher efficacy to kill cancer cells compared with chemotherapy and photothermal therapy alone. Hence, ZIF-8/GQD nanoparticles would be promising as versatile nanocarriers for synergistic cancer therapy.

Involved external institutions

University of Shanghai for Science and Technology (USST) CN China (CN) Huanggang Normal University CN China (CN) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Tian, Z., Yao, X., Ma, K., Niu, X., Grothe, J., Xu, Q.,... Zhu, Y. (2017). Metal-Organic Framework/Graphene Quantum Dot Nanoparticles Used for Synergistic Chemo- and Photothermal Therapy. ACS Omega, 2(3), 1249-1258. https://doi.org/10.1021/acsomega.6b00385

MLA:

Tian, Zhengfang, et al. "Metal-Organic Framework/Graphene Quantum Dot Nanoparticles Used for Synergistic Chemo- and Photothermal Therapy." ACS Omega 2.3 (2017): 1249-1258.

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