Reactive oxygen species-responsive RNA interference

Rühle J, Klemt I, Abakumova T, Sergeeva O, Vetosheva P, Zatsepin T, Mokhir A (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Chemical Communications Royal Society of Chemistry

DOI: 10.1039/d2cc00651k

Abstract

Due to oxidative instability, arylboronic acids are not compatible with the solid-phase synthesis of nucleic acids. We solved this problem and, based on these findings, developed siRNA prodrugs activated in the presence of reactive oxygen species (ROS) in vivo. These prodrugs can be used for specific targeting of ROS-rich cancer cells.

Authors with CRIS profile

Jennifer Rühle Lehrstuhl für Organische Chemie II Insa Klemt Lehrstuhl für Organische Chemie II Andriy Mokhir Professur für Organische Chemie

Involved external institutions

Skolkovo Institute of Science and Technology RU Russian Federation (RU)

How to cite

APA:

Rühle, J., Klemt, I., Abakumova, T., Sergeeva, O., Vetosheva, P., Zatsepin, T., & Mokhir, A. (2022). Reactive oxygen species-responsive RNA interference. Chemical Communications. https://doi.org/10.1039/d2cc00651k

MLA:

Rühle, Jennifer, et al. "Reactive oxygen species-responsive RNA interference." Chemical Communications (2022).

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