ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series

Glückstein MI, Dintner S, Miller S, Vlasenko D, Schenkirsch G, Agaimy A, Märkl B, Grosser B (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Diagnostics MDPI

Book Volume: 12

Article Number: 429

Journal Issue: 2

DOI: 10.3390/diagnostics12020429

Abstract

ALK, NUT, and TRK are rare molecular aberrations that are pathognomonic for specific rare tumors. In low frequencies, however, they are found in a wide range of other tumor entities. This study aimed to investigate the frequency, association with clinicopathological characteristics, and prognosis of the immunohistochemical expressions of ALK, NUT, and TRK in 477 adenocarcinomas of the stomach and gastroesophageal junction. Seven cases (1.5%) showed an expression of TRK. In NGS, no NTRK fusion was confirmed. No case with ALK or NUT expression was detected. ALK, NUT, and NTRK expression does not seem to play an important role in gastric carcinomas.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Universität Augsburg DE Germany (DE)

How to cite

APA:

Glückstein, M.I., Dintner, S., Miller, S., Vlasenko, D., Schenkirsch, G., Agaimy, A.,... Grosser, B. (2022). ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series. Diagnostics, 12(2). https://doi.org/10.3390/diagnostics12020429

MLA:

Glückstein, Marie Isabelle, et al. "ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series." Diagnostics 12.2 (2022).

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