Omata Y, Frech M, Saito T, Schett G, Zaiss M, Tanaka S (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Book Volume: 23
Article Number: 1104
Journal Issue: 3
DOI: 10.3390/ijms23031104
While type 2 immunity has traditionally been associated with the control of parasitic infections and allergic reactions, increasing evidence suggests that type 2 immunity exerts regulatory functions on inflammatory diseases such as arthritis, and also on bone homeostasis. This review summarizes the current evidence of the regulatory role of type 2 immunity in arthritis and bone. Key type 2 cytokines, like interleukin (IL)-4 and IL-13, but also others such as IL-5, IL-9, IL-25, and IL-33, exert regulatory properties on arthritis, dampening inflammation and inducing resolution of joint swelling. Furthermore, these cytokines share anti-osteoclastogenic properties and thereby reduce bone resorption and protect bone. Cellular effectors of this action are both T cells (i.e., Th2 and Th9 cells), but also non-T cells, like type 2 innate lymphoid cells (ILC2). Key regulatory actions mediated by type 2 cytokines and immune cells on both inflammation as well as bone homeostasis are discussed.
APA:
Omata, Y., Frech, M., Saito, T., Schett, G., Zaiss, M., & Tanaka, S. (2022). Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity. International Journal of Molecular Sciences, 23(3). https://doi.org/10.3390/ijms23031104
MLA:
Omata, Yasunori, et al. "Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity." International Journal of Molecular Sciences 23.3 (2022).
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