Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology
Maubach G, Vieth M, Boccellato F, Naumann M (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
DOI: 10.1016/j.molmed.2021.12.005
Abstract
NF-κB signaling pathways, induced by a variety of triggers, play a key role in regulating the expression of genes involved in the immune response and cellular responses to stress. The human pathogen Helicobacter pylori induces classical and alternative NF-κB signaling pathways via its effector ADP-L-glycero-β-D-manno-heptose (ADP-heptose). We review H. pylori- and NF-κB-dependent alterations in cellular processes and associated maladaptation leading to deleterious gastric pathophysiology that have implications for the diagnosis and treatment of gastric diseases. Therapeutic options for gastric cancer (GC) include clinically relevant small molecule inhibitors of NF-κB and epigenetic therapy approaches. In this context, gastric organoid biobanks originated from patient material, represent a valuable platform for translational applications to predict patient responses to chemotherapy, with a view to personalized medicine.
Authors with CRIS profile
Involved external institutions
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
University of Oxford
United Kingdom (GB)
Klinikum Bayreuth
Germany (DE)
Germany (DE)
University of Oxford
United Kingdom (GB)
Klinikum Bayreuth
Germany (DE)
How to cite
APA:
Maubach, G., Vieth, M., Boccellato, F., & Naumann, M. (2022). Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2021.12.005
MLA:
Maubach, Gunter, et al. "Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology." Trends in Molecular Medicine (2022).
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