Consensus on diagnosis and management of Cushing's disease: a guideline update

Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, Mccormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Book Volume: 9

Pages Range: 847-875

Journal Issue: 12

DOI: 10.1016/S2213-8587(21)00235-7

Abstract

Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management to optimise patient outcomes. The Pituitary Society convened a consensus workshop comprising more than 50 academic researchers and clinical experts to discuss the application of recent evidence to clinical practice. In advance of the virtual meeting, data from 2015 to present about screening and diagnosis; surgery, medical, and radiation therapy; and disease-related and treatment-related complications of Cushing's disease summarised in recorded lectures were reviewed by all participants. During the meeting, concise summaries of the recorded lectures were presented, followed by small group breakout discussions. Consensus opinions from each group were collated into a draft document, which was reviewed and approved by all participants. Recommendations regarding use of laboratory tests, imaging, and treatment options are presented, along with algorithms for diagnosis of Cushing's syndrome and management of Cushing's disease. Topics considered most important to address in future research are also identified.

Authors with CRIS profile

Involved external institutions

ENDOC Praxis für Endokrinologie, Andrologie und medikamentöse Tumortherapie Germany (DE) University College London (UCL) United Kingdom (GB) Hospital de la Santa Creu i Sant Pau Spain (ES) Brigham and Women's Hospital (BWH) United States (USA) (US) Cedars-Sinai Medical Center United States (USA) (US) University of Padua / Universita degli Studi di Padova Italy (IT) Northwestern University United States (USA) (US) Garvan Institute of Medical Research Australia (AU) Medizinische Universität Wien Austria (AT) Massachusetts General Hospital United States (USA) (US) École Polytechnique - Université Paris-Saclay France (FR) Rabin Medical Center / מרכז רפואי רבין‎‎ Israel (IL) University of Cambridge United Kingdom (GB) Oregon Health and Science University (OSHU) United States (USA) (US) Leiden University Medical Center Netherlands (NL) Medical College of Wisconsin (MCW) United States (USA) (US) Evangelismos Medical Center Greece (GR) Universidade Federal do Rio de Janeiro (UFRJ) / Federal University of Rio de Janeiro Brazil (BR) Pacific Neuroscience Institute (PNI) United States (USA) (US) Stanford University United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) Ludwig-Maximilians-Universität (LMU) Germany (DE) Institut national de physique nucléaire et de physique des particules (IN2P3) France (FR) University of Southern California (USC) United States (USA) (US) Johns Hopkins University (JHU) United States (USA) (US) Università degli Studi di Ferrara Italy (IT) University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne France (FR) Universidade Federal do Paraná (UFPR) Brazil (BR) University of Santiago de Compostela / Universidad de Santiago de Compostela (USC) Spain (ES) University of Sheffield United Kingdom (GB) Aix-Marseille University / Aix-Marseille Université France (FR) Università degli Studi di Napoli Federico II Italy (IT) Università Vita-Salute San Raffaele (UniSR) Italy (IT) University of Michigan United States (USA) (US) Hospital General de Catalunya Spain (ES) US National Institutes of Health (NIH) United States (USA) (US) Université de Montréal Canada (CA) Oxford University Hospitals NHS Foundation Trust United Kingdom (GB) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) University of Birmingham United Kingdom (GB) Mayo Clinic United States (USA) (US) Nara Medical University Japan (JP) Emory University United States (USA) (US)

How to cite

APA:

Fleseriu, M., Auchus, R., Bancos, I., Ben-Shlomo, A., Bertherat, J., Biermasz, N.R.,... Biller, B.M.K. (2021). Consensus on diagnosis and management of Cushing's disease: a guideline update. Lancet Diabetes and Endocrinology, 9(12), 847-875. https://doi.org/10.1016/S2213-8587(21)00235-7

MLA:

Fleseriu, Maria, et al. "Consensus on diagnosis and management of Cushing's disease: a guideline update." Lancet Diabetes and Endocrinology 9.12 (2021): 847-875.

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