Is There Any Evidence of Monocytes Involvement in Alzheimer's Disease? A Pilot Study on Human Postmortem Brain
Monoranu CM, Hartmann T, Strobel S, Heinsen H, Riederer P, Distel L, Bohnert S (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 5
Pages Range: 887-897
Journal Issue: 1
DOI: 10.3233/ADR-210052
Abstract
Background: The role of neuroinflammation has become more evident in the pathogenesis of neurodegenerative diseases. Increased expression of microglial markers is widely reported in Alzheimer's disease (AD), but much less is known about the role of monocytes in AD pathogenesis. In AD animal models, bone marrow-derived monocytes appear to infiltrate the parenchyma and contribute to the phagocytosis of amyloid-beta depositions, but this infiltration has not been established in systematic studies of the human brain postmortem.
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Germany (DE)How to cite
APA:
Monoranu, C.-M., Hartmann, T., Strobel, S., Heinsen, H., Riederer, P., Distel, L., & Bohnert, S. (2021). Is There Any Evidence of Monocytes Involvement in Alzheimer's Disease? A Pilot Study on Human Postmortem Brain. Journal of Alzheimer's Disease Reports, 5(1), 887-897. https://doi.org/10.3233/ADR-210052
MLA:
Monoranu, Camelia-Maria, et al. "Is There Any Evidence of Monocytes Involvement in Alzheimer's Disease? A Pilot Study on Human Postmortem Brain." Journal of Alzheimer's Disease Reports 5.1 (2021): 887-897.
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