A Comparison of Single- and Multiparametric MRI Models for Differentiation of Recurrent Glioblastoma from Treatment-Related Change

Eisenhut F, Engelhorn T, Arinrad S, Brandner S, Coras R, Putz F, Fietkau R, Dörfler A, Schmidt M (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Diagnostics MDPI

Book Volume: 11

Journal Issue: 12

DOI: 10.3390/diagnostics11122281

Abstract

To evaluate single- and multiparametric MRI models to differentiate recurrent glioblastoma (GBM) and treatment-related changes (TRC) in clinical routine imaging. Selective and unselective apparent diffusion coefficient (ADC) and minimum, mean, and maximum cerebral blood volume (CBV) measurements in the lesion were performed. Minimum, mean, and maximum ratios(CBV) (CBVlesion to CBVhealthy white matter) were computed. All data were tested for lesion discrimination. A multiparametric model was compiled via multiple logistic regression using data demonstrating significant difference between GBM and TRC and tested for its diagnostic strength in an independent patient cohort. A total of 34 patients (17 patients with recurrent GBM and 17 patients with TRC) were included. ADC measurements showed no significant difference between both entities. All CBV and ratios(CBV) measurements were significantly higher in patients with recurrent GBM than TRC. A minimum CBV of 8.5, mean CBV of 116.5, maximum CBV of 327 and ratio(CBV) (minimum) of 0.17, ratio(CBV) (mean) of 2.26 and ratio(CBV) (maximum) of 3.82 were computed as optimal cut-off values. By integrating these parameters in a multiparametric model and testing it in an independent patient cohort, 9 of 10 patients, i.e., 90%, were classified correctly. The multiparametric model further improves radiological discrimination of GBM from TRC in comparison to single-parameter approaches and enables reliable identification of recurrent tumors.

Authors with CRIS profile

Felix Eisenhut Department of Neuroradiology Tobias Martin Engelhorn Department of Neuroradiology Soheil Arinrad Department of Neurosurgery Sebastian Brandner Medizinische Fakultät Roland Coras Institute of Neuropathology Florian Putz Department of Radiation Oncology Rainer Fietkau Lehrstuhl für Strahlentherapie Arnd Dörfler Department of Neuroradiology Manuel Schmidt Department of Neuroradiology

How to cite

APA:

Eisenhut, F., Engelhorn, T., Arinrad, S., Brandner, S., Coras, R., Putz, F.,... Schmidt, M. (2021). A Comparison of Single- and Multiparametric MRI Models for Differentiation of Recurrent Glioblastoma from Treatment-Related Change. Diagnostics, 11(12). https://doi.org/10.3390/diagnostics11122281

MLA:

Eisenhut, Felix, et al. "A Comparison of Single- and Multiparametric MRI Models for Differentiation of Recurrent Glioblastoma from Treatment-Related Change." Diagnostics 11.12 (2021).

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