Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype
Stachyra K, Wiśniewska A, Kiepura A, Kuś K, Rolski F, Czepiel K, Chmura Ł, Majka G, Surmiak M, Polaczek J, van Eldik R, Suski M, Olszanecki R (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 230
Article Number: 113112
DOI: 10.1016/j.ecoenv.2021.113112
Abstract
Background and aims: Exposure to environmental nanoparticles is related to the adverse impact on health, including cardiovascular system. Various forms of nanoparticles have been reported to interact with endothelium and induce inflammation. However, the potential role of nanoparticles in the pathogenesis of atherosclerosis and their mechanisms of action are still unclear. The aim of this study was to investigate the effect of two broadly used nanomaterials, which also occur in natural environment - silicon oxide (SiO2) and ferric oxide (Fe2O3) in the form of nanoparticles (NPs) - on the development of atherosclerosis. Methods: We used apolipoprotein E-knockout mice exposed to silica and ferric oxide nanoparticles in a whole body inhalation chamber. Results: Inhaled silica nanoparticles augmented the atherosclerotic lesions and increased the percentage of pro-inflammatory M1 macrophages in both the plaque and the peritoneum in apoE-/- mice. Exposure to ferric oxide nanoparticles did not enhance atherogenesis process, however, it caused significant changes in the atherosclerotic plaque composition (elevated content of CD68-positive macrophages and enlarged necrotic core accompanied by the decreased level of M1 macrophages). Both silica and ferric oxide NPs altered the phenotype of T lymphocytes in the spleen by promoting polarization towards Th17 cells. Conclusions: Exposure to silica and ferric oxide nanoparticles exerts impact on atherosclerosis development and plaque composition. Pro-atherogenic abilities of silica nanoparticles are associated with activation of pro-inflammatory macrophages.
Authors with CRIS profile
Involved external institutions
Jagiellonian University Medical College
Poland (PL)
University Children’s Hospital / Uniwersytecki Szpital Dziecięcy
Poland (PL)
Jagiellonian University / Uniwersytet Jagielloński (UJ)
Poland (PL)
Poland (PL)
University Children’s Hospital / Uniwersytecki Szpital Dziecięcy
Poland (PL)
Jagiellonian University / Uniwersytet Jagielloński (UJ)
Poland (PL)
How to cite
APA:
Stachyra, K., Wiśniewska, A., Kiepura, A., Kuś, K., Rolski, F., Czepiel, K.,... Olszanecki, R. (2022). Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype. Ecotoxicology and Environmental Safety, 230. https://doi.org/10.1016/j.ecoenv.2021.113112
MLA:
Stachyra, Kamila, et al. "Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype." Ecotoxicology and Environmental Safety 230 (2022).
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