Bock L, Schultheiss SK, Maschauer S, Lasch R, Gradl S, Prante O, Zard SZ, Heinrich M (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 2021
Pages Range: 6258-6262
Journal Issue: 46
The synthesis of 2-[18F]trifluoromethylated indoles from the corresponding chlorodifluoromethyl precursors was found to proceed under milder conditions when compared to known metal-free nucleophilic exchange reactions with [18F]fluoride on chlorodifluoro-methyl arenes. A key element in the reaction course is – most likely – a favorable elimination-addition mechanism on the 2-methyl position of the indole. Given the increasing interest in 18F-labelled compounds, this single step labeling methodology nicely complements the so far existing routes to 2-[18F]trifluoromethylated indoles.
APA:
Bock, L., Schultheiss, S.K., Maschauer, S., Lasch, R., Gradl, S., Prante, O.,... Heinrich, M. (2021). Synthesis of 2-(Chlorodifluoromethyl)indoles for Nucleophilic Halogen Exchange with [18F]Fluoride. European Journal of Organic Chemistry, 2021(46), 6258-6262. https://doi.org/10.1002/ejoc.202100937
MLA:
Bock, Leonard, et al. "Synthesis of 2-(Chlorodifluoromethyl)indoles for Nucleophilic Halogen Exchange with [18F]Fluoride." European Journal of Organic Chemistry 2021.46 (2021): 6258-6262.
BibTeX: Download