Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Tin A, Schlosser P, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Yu Z, Weihs A, Hoppmann A, Grundner-Culemann F, Min JL, Kuhns VLH, Adeyemo AA, Agyemang C, Arnlov J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Bressler J, Breteler MMB, Carmeli C, Chaker L, Coresh J, Corre T, Correa A, Cox SR, Delgado GE, Eckardt KU, Ekici AB, Endlich K, Floyd JS, Fraszczyk E, Gao X, Gao X, Gelber AC, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kronenberg F, Kuehnel B, Ladd-Acosta C, Lehtimaki T, Lind L, Liu D, Lloyd-Jones DM, Lorkowski S, Lu AT, Marioni RE, Marz W, Mccartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Schottker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundstrom J, Swenson BR, Van Meurs JBJ, Van Vliet-Ostaptchouk JV, Venema A, Volker U, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y, Loh M, Snieder H, Waldenberger M, Levy D, Akilesh S, Woodward OM, Susztak K, Teumer A, Kottgen A (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 12

Journal Issue: 1

DOI: 10.1038/s41467-021-27198-4

Abstract

Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS loci and shared CpGs of urate and cardiometabolic traits.

Authors with CRIS profile

Involved external institutions

Johns Hopkins University (JHU) United States (USA) (US) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) Framingham Heart Study United States (USA) (US) University of Pennsylvania United States (USA) (US) Eli and Edythe L. Broad Institute of MIT and Harvard United States (USA) (US) Universitätsmedizin Greifswald / Universitätsklinikum Greifswald Germany (DE) Albert-Ludwigs-Universität Freiburg Germany (DE) University of Mississippi (Ole Miss) United States (USA) (US) Université de Lausanne (UNIL) Switzerland (CH) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) University of Bristol United Kingdom (GB) University of Maryland United States (USA) (US) National Human Genome Research Institute (NHGRI) United States (USA) (US) University of Amsterdam Netherlands (NL) Karolinska Institute Sweden (SE) Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Germany (DE) Columbia University United States (USA) (US) University of Texas Health Science Center at Houston (UTHealth) United States (USA) (US) Erasmus University Medical Center (MC) Netherlands (NL) University of Edinburgh United Kingdom (GB) Ruprecht-Karls-Universität Heidelberg Germany (DE) University of Washington United States (USA) (US) Northwestern University United States (USA) (US) Heinrich-Heine-Universität Düsseldorf Germany (DE) University of California Los Angeles (UCLA) United States (USA) (US) University of Tampere (UTA) / Tampereen yliopisto (Tay) Finland (FI) University of Michigan United States (USA) (US) University of Tartu Estonia (EE) Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.) Germany (DE) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) Medizinische Universität Innsbruck Austria (AT) Uppsala University Sweden (SE) Friedrich-Schiller-Universität Jena Germany (DE) Technische Universität München (TUM) Germany (DE) University of Turku / Turun yliopisto Finland (FI) Harvard University United States (USA) (US) University of Minnesota (UMN) United States (USA) (US) University of Groningen / Rijksuniversiteit Groningen Netherlands (NL) Nanyang Technological University (NTU) Singapore (SG)

How to cite

APA:

Tin, A., Schlosser, P., Matias-Garcia, P.R., Thio, C.H.L., Joehanes, R., Liu, H.,... Kottgen, A. (2021). Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27198-4

MLA:

Tin, Adrienne, et al. "Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus." Nature Communications 12.1 (2021).

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