Friscic J, Hoffmann M (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Book Volume: 74
Pages Range: 92-99
DOI: 10.1016/j.coi.2021.10.006
In the last fifteen years it has become apparent that tissue resident mesenchymal cells such as fibroblasts, which are the structural elements of all organs, play a cardinal role in the pathology of immune-mediated inflammatory diseases. We now know that all fibroblasts originate from universal pan organ cellular ancestors and that they are diversified into more specific subsets according to the functional needs of their home tissue-and its activation state. In arthritis, a plethora of activated joint-resident and migrating fibroblast types have been recently described that are central for pathogenesis and persistence of inflammatory joint-disease. Here we provide a current overview on the multiple inflammatory and immune related functions of fibroblasts and how they could be curbed to induce long-lasting abatement of disease.
APA:
Friscic, J., & Hoffmann, M. (2022). Stromal cell regulation of inflammatory responses. Current Opinion in Immunology, 74, 92-99. https://doi.org/10.1016/j.coi.2021.10.006
MLA:
Friscic, Jasna, and Markus Hoffmann. "Stromal cell regulation of inflammatory responses." Current Opinion in Immunology 74 (2022): 92-99.
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