The use of PAMG-1 testing in patients with preterm labor, intact membranes and a short sonographic cervix reduces the rate of unnecessary antenatal glucocorticoid administration

Kehl S, Weiss C, Pretscher J, Baier F, Faschingbauer F, Beckmann M, Stumpfe F (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 49

Pages Range: 1135-1140

Journal Issue: 9

DOI: 10.1515/jpm-2021-0048

Abstract

Objectives: To assess the frequency of antenatal corticosteroid (ACS) administration in cases with shortened cervical length by addition of placental alpha-microglobulin-1 (PAMG-1) testing to sonographic examination. Methods: Single centre retrospective cohort study. Rate of ACS administration was compared between cases with cervical length between 15 and 25 mm and cases with positive PAMG-1 testing and cervical length between 15 and 25 mm. We evaluated the following outcome parameters: Rate of ACS administration, gestational age at delivery, time to delivery, delivery within seven days, delivery <34 and <37 weeks' gestation, rate of admission to neonatal intensive care unit (NICU). Results: In total, 130 cases were included. "PAMG-1 group" consisted of 68 women, 62 cases built the "historical control group". ACS administration was performed less frequently in the "PAMG-1 cohort" (18 (26%) vs. 46 (74%); p<0.001). The rate of delivery within seven days did not differ (2 (3%) vs. 4 (6.5%); p=0.4239). The rates of delivery <34 weeks' gestation (7 (10%) vs. 9 (15%); p=0.4643) and <37 weeks' gestation (19 (28%) vs. 26 (42%); p=0.0939) did not differ. Time to delivery interval was longer in the PAMG-1 group (61.5 vs. 43 days, p=0.0117). NICU admission occurred more often in the "historical control group" (22 (38%) vs. 28 (60%); p=0.0272). Conclusions: Addition of biomarker testing can help to avoid unnecessary ACS administrations in women with shortened cervical length.

Authors with CRIS profile

Involved external institutions

Ruprecht-Karls-Universität Heidelberg Germany (DE)

How to cite

APA:

Kehl, S., Weiss, C., Pretscher, J., Baier, F., Faschingbauer, F., Beckmann, M., & Stumpfe, F. (2021). The use of PAMG-1 testing in patients with preterm labor, intact membranes and a short sonographic cervix reduces the rate of unnecessary antenatal glucocorticoid administration. Journal of Perinatal Medicine, 49(9), 1135-1140. https://doi.org/10.1515/jpm-2021-0048

MLA:

Kehl, Sven, et al. "The use of PAMG-1 testing in patients with preterm labor, intact membranes and a short sonographic cervix reduces the rate of unnecessary antenatal glucocorticoid administration." Journal of Perinatal Medicine 49.9 (2021): 1135-1140.

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