Toward Deep Biophysical Cytometry: Prospects and Challenges
Lee KC, Goda K, Tsia KK, Guck J (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 39
Pages Range: 1249-1262
Journal Issue: 12
DOI: 10.1016/j.tibtech.2021.03.006
Abstract
The biophysical properties of cells reflect their identities, underpin their homeostatic state in health, and define the pathogenesis of disease. Recent leapfrogging advances in biophysical cytometry now give access to this information, which is obscured in molecular assays, with a discriminative power that was once inconceivable. However, biophysical cytometry should go 'deeper' in terms of exploiting the information-rich cellular biophysical content, generating a molecular knowledge base of cellular biophysical properties, and standardizing the protocols for wider dissemination. Overcoming these barriers, which requires concurrent innovations in microfluidics, optical imaging, and computer vision, could unleash the enormous potential of biophysical cytometry not only for gaining a new mechanistic understanding of biological systems but also for identifying new cost-effective biomarkers of disease.
Authors with CRIS profile
Involved external institutions
University of Hong Kong (HKU) / 香港大學
Hong Kong (HK)
University of Tokyo
Japan (JP)
Max-Planck-Institut für die Physik des Lichts (MPL) / Max Planck Institute for the Science of Light
Germany (DE)
Hong Kong (HK)
University of Tokyo
Japan (JP)
Max-Planck-Institut für die Physik des Lichts (MPL) / Max Planck Institute for the Science of Light
Germany (DE)
How to cite
APA:
Lee, K.C., Goda, K., Tsia, K.K., & Guck, J. (2021). Toward Deep Biophysical Cytometry: Prospects and Challenges. Trends in Biotechnology, 39(12), 1249-1262. https://doi.org/10.1016/j.tibtech.2021.03.006
MLA:
Lee, Kelvin C.M., et al. "Toward Deep Biophysical Cytometry: Prospects and Challenges." Trends in Biotechnology 39.12 (2021): 1249-1262.
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