Shedding of app limits its synaptogenic activity and cell adhesion properties

Stahl R, Schilling S, Soba P, Rupp C, Hartmann T, Wagner K, Merdes G, Eggert S, Kins S (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Frontiers in Cellular Neuroscience Frontiers Research Foundation / Frontiers Media

Book Volume: 8

Article Number: 410

Journal Issue: DEC

DOI: 10.3389/fncel.2014.00410

Abstract

The amyloid precursor protein (APP) plays a central role in Alzheimer's disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its extracellular domain. Since neuronal APP is extensively processed by secretases, it raises the question if APP shedding affects its cell adhesion and synaptogenic properties. We show that inhibition of APP shedding using cleavage deficient forms of APP or a dominant negative a-secretase strongly enhanced its cell adhesion and synaptogenic activity suggesting that synapse promoting function of APP is tightly regulated by a-secretase mediated processing, similar to other trans-cellular synaptic adhesion molecules.

Authors with CRIS profile

Peter Soba

Involved external institutions

Technische Universität Kaiserslautern DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Universität des Saarlandes (UdS) DE Germany (DE) Universität Hamburg (UHH) DE Germany (DE)

How to cite

APA:

Stahl, R., Schilling, S., Soba, P., Rupp, C., Hartmann, T., Wagner, K.,... Kins, S. (2014). Shedding of app limits its synaptogenic activity and cell adhesion properties. Frontiers in Cellular Neuroscience, 8(DEC). https://doi.org/10.3389/fncel.2014.00410

MLA:

Stahl, Ronny, et al. "Shedding of app limits its synaptogenic activity and cell adhesion properties." Frontiers in Cellular Neuroscience 8.DEC (2014).

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