The ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion

Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN (2015)

Publication Type: Journal article

Publication year: 2015

Journal

eLife eLife Sciences Publications

Book Volume: 2015

Journal Issue: 4

DOI: 10.7554/eLife.05491

Abstract

Neurons develop highly stereotyped receptive fields by coordinated growth of their dendrites. Although cell surface cues play a major role in this process, few dendrite specific signals have been identified to date. We conducted an in vivo RNAi screen in Drosophila class IV dendritic arborization (C4da) neurons and identified the conserved Ret receptor, known to play a role in axon guidance, as an important regulator of dendrite development. The loss of Ret results in severe dendrite defects due to loss of extracellular matrix adhesion, thus impairing growth within a 2D plane. We provide evidence that Ret interacts with integrins to regulate dendrite adhesion via racl. In addition, Ret is required for dendrite stability and normal F-actin distribution suggesting it has an essential role in dendrite maintenance. We propose novel functions for Ret as a regulator in dendrite patterning and adhesion distinct from its role in axon guidance.

Authors with CRIS profile

Peter Soba

Involved external institutions

Universität Hamburg (UHH) DE Germany (DE) University of California San Francisco (UCSF) US United States (USA) (US) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB)

How to cite

APA:

Soba, P., Han, C., Zheng, Y., Perea, D., Miguel-Aliaga, I., Jan, L.Y., & Jan, Y.N. (2015). The ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. eLife, 2015(4). https://doi.org/10.7554/eLife.05491

MLA:

Soba, Peter, et al. "The ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion." eLife 2015.4 (2015).

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