Mahn M, Saraf-Sinik I, Patil P, Pulin M, Bitton E, Karalis N, Bruentgens F, Palgi S, Gat A, Dine J, Wietek J, Davidi I, Levy R, Litvin A, Zhou F, Sauter K, Schmitz D, Luthi A, Rost BR, Wiegert JS, Yizhar O, Soba P (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 109
Pages Range: 1621-1635.e8
Journal Issue: 10
DOI: 10.1016/j.neuron.2021.03.013
Information is carried between brain regions through neurotransmitter release from axonal presynaptic terminals. Understanding the functional roles of defined neuronal projection pathways requires temporally precise manipulation of their activity. However, existing inhibitory optogenetic tools have low efficacy and off-target effects when applied to presynaptic terminals, while chemogenetic tools are difficult to control in space and time. Here, we show that a targeting-enhanced mosquito homolog of the vertebrate encephalopsin (eOPN3) can effectively suppress synaptic transmission through the G
APA:
Mahn, M., Saraf-Sinik, I., Patil, P., Pulin, M., Bitton, E., Karalis, N.,... Soba, P. (2021). Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin. Neuron, 109(10), 1621-1635.e8. https://doi.org/10.1016/j.neuron.2021.03.013
MLA:
Mahn, Mathias, et al. "Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin." Neuron 109.10 (2021): 1621-1635.e8.
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