Protektive Makrophagen: Neue Einblicke zur Rolle von Synovialmakrophagen bei entzündlichen Gelenkerkrankungen

Knab K, Chambers D, Krönke G (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Zeitschrift für Rheumatologie Springer Verlag

Abstract

Macrophages are among the phylogenetically oldest cells of the immune system and are found in all tissues and organs. In addition to playing an important role in immune response against pathogenic microorganisms, these cells were previously described to play a vital role in chronic inflammatory diseases such as rheumatoid arthritis. Using novel techniques such as single-cell sequencing and advanced microscopy techniques it has now been shown that macrophages are far more versatile. Thus, these cells contribute considerably to tissue homeostasis and tissue regeneration. As each tissue has to fulfill special requirements, macrophages vary in their phenotype and function between organs. New data have now identified a specialised population of epithelioid macrophages that exert a protective and anti-inflammatory function in synovial tissue and prevent the initial onset as well as episodes of joint inflammation in rheumatoid arthritis.

Authors with CRIS profile

Katharina Knab Department of Medicine 3 – Rheumatology and Immunology David Chambers Department of Medicine 3 – Rheumatology and Immunology Gerhard Krönke Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Knab, K., Chambers, D., & Krönke, G. (2021). Protektive Makrophagen: Neue Einblicke zur Rolle von Synovialmakrophagen bei entzündlichen Gelenkerkrankungen. Zeitschrift für Rheumatologie. https://doi.org/10.1007/s00393-021-01112-1

MLA:

Knab, Katharina, David Chambers, and Gerhard Krönke. "Protektive Makrophagen: Neue Einblicke zur Rolle von Synovialmakrophagen bei entzündlichen Gelenkerkrankungen." Zeitschrift für Rheumatologie (2021).

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