Hemophagocytic lymphohistiocytosis and thrombotic microangiopathy after parvovirus B19 infection and renal transplantation: a case report
Steffen CJ, Koch N, Eckardt KU, Amann KU, Seelow E, Schreiber A (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 22
Article Number: 337
Journal Issue: 1
DOI: 10.1186/s12882-021-02538-0
Abstract
Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease characterized by hyperactivation of the immune system that causes hypercytokinemia and potentially multi organ failure. HLH can occur in patients with underlying rheumatic or autoinflammatory disorders. Additionally, HLH can develop in patients during infections or malignancies without a known genetic predisposition. Case presentation: We herein report a patient, who presented with fever, both acute kidney and liver injury, anemia, thrombocytopenia and HSV stomatitis. HLH was diagnosed based on clinical criteria and qPCR revealed an acute parvovirus B19 infection as potential underlying infectious trigger. Treatment was started with both IVIG and dexamethasone. Subsequently, kidney biopsy demonstrated TMA. Conclusions: In rare cases both HLH and aHUS can occur simultaneously in a patient as a consequence of viral infections. Insights from this unusual case might help physicians understand this complex symptom constellation.
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Germany (DE)How to cite
APA:
Steffen, C.J., Koch, N., Eckardt, K.U., Amann, K.U., Seelow, E., & Schreiber, A. (2021). Hemophagocytic lymphohistiocytosis and thrombotic microangiopathy after parvovirus B19 infection and renal transplantation: a case report. BMC Nephrology, 22(1). https://doi.org/10.1186/s12882-021-02538-0
MLA:
Steffen, C. J., et al. "Hemophagocytic lymphohistiocytosis and thrombotic microangiopathy after parvovirus B19 infection and renal transplantation: a case report." BMC Nephrology 22.1 (2021).
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