Ruhm L, Avdievich N, Ziegs T, Nagel AM, De Feyter HM, de Graaf RA, Henning A (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 244
Article Number: 118639
DOI: 10.1016/j.neuroimage.2021.118639
Purpose: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. Methods: The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. Results: The metabolism of [6,6′-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. Conclusion: X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.
APA:
Ruhm, L., Avdievich, N., Ziegs, T., Nagel, A.M., De Feyter, H.M., de Graaf, R.A., & Henning, A. (2021). Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution. NeuroImage, 244. https://doi.org/10.1016/j.neuroimage.2021.118639
MLA:
Ruhm, Loreen, et al. "Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution." NeuroImage 244 (2021).
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