Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes

Sahoo SS, Pastor VB, Goodings C, Voss RK, Kozyra EJ, Szvetnik A, Noellke P, Dworzak M, Stary J, Locatelli F, Masetti R, Schmugge M, De Moerloose B, Catala A, Kallay K, Turkiewicz D, Hasle H, Buechner J, Jahnukainen K, Ussowicz M, Polychronopoulou S, Smith OP, Fabri O, Barzilai S, De Haas V, Baumann I, Schwarz-Furlan S, Niewisch MR, Sauer MG, Burkhardt B, Lang P, Bader P, Beier R, Mueller I, Albert MH, Meisel R, Schulz A, Cario G, Panda PK, Wehrle J, Hirabayashi S, Derecka M, Durruthy-Durruthy R, Goehring G, Yoshimi-Noellke A, Ku M, Lebrecht D, Erlacher M, Flotho C, Strahm B, Niemeyer CM, Wlodarski MW (2021)

Publication Type: Journal article

Publication year: 2021

Journal

DOI: 10.1038/s41591-021-01511-6

Abstract

This analysis of a large, clinically annotated cohort of individuals with predisposition to myelodysplastic syndromes reveals insights into the genetic determinants of disease progression and their relationship with clinical manifestations and therapy outcome.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Albert-Ludwigs-Universität Freiburg Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Heinrich-Heine-Universität Düsseldorf Germany (DE) Universitätsklinikum Münster Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Medizinische Universität Wien Austria (AT) Universiteit Gent (UGent) / Ghent University Belgium (BE) Eberhard Karls Universität Tübingen Germany (DE) Hospital Sant Joan de Déu Barcelona Spain (ES) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Temple Street Children's University Hospital / Children's Health Ireland (CHI) Ireland (IE) Tel Aviv University Israel (IL) Dutch Childhood Oncology Group Netherlands (NL) Universitäts-Kinderspital Zürich Switzerland (CH) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) Universitätsklinikum Ulm Germany (DE) Institut für Pathologie Kaufbeuren-Ravensburg GbR Germany (DE) Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu Poland (PL) Ludwig-Maximilians-Universität (LMU) Germany (DE) Univerzita Karlova v Praze / Charles University in Prague Czech Republic (CZ) St. Jude Children’s Research Hospital United States (USA) (US) Universitätsklinikum Essen Germany (DE) Ospedaliero Universitaria di Bologna Policlinico S.Orsola-Malpighi Italy (IT) Comenius University Bratislava Slovakia (SK) "Aghia Sofia" General Children's Hospital Greece (GR) Università degli studi "La Sapienza" Italy (IT) Skåne University Hospital / Skånes universitetssjukhus Sweden (SE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Helsingin yliopisto / University of Helsinki Finland (FI) Mission Bio Ltd. United States (USA) (US)

How to cite

APA:

Sahoo, S.S., Pastor, V.B., Goodings, C., Voss, R.K., Kozyra, E.J., Szvetnik, A.,... Wlodarski, M.W. (2021). Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes. Nature Medicine. https://doi.org/10.1038/s41591-021-01511-6

MLA:

Sahoo, Sushree S., et al. "Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes." Nature Medicine (2021).

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