Steeb T, Wessely A, Petzold A, Kohl C, Erdmann M, Berking C, Heppt M (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Book Volume: 157
Pages Range: 348-357
DOI: 10.1016/j.ejca.2021.08.015
Background: Activating genomic alterations of the receptor tyrosine kinase KIT are found preferentially in certain melanoma subtypes such as acral and mucosal melanoma or melanoma arising in chronically sun-damaged skin. However, the therapeutic value of c Kit inhibitors for these subtypes currently remains unclear. Objectives: The objective of this study was to summarise the efficacy and safety of c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma. Methods: We performed a systematic literature research in MEDLINE, Embase and CENTRAL and hand searched pertinent trial registers and conference abstracts for eligible trials until 23rd June 2020. Results were pooled using a random-effects model to calculate pooled proportions of objective response rates (ORRs) and severe adverse events (sAEs) from unselected KIT mutant or amplified cohorts. Results: Nineteen single-arm studies with an overall sample size of 601 patients were included. The studies investigated imatinib (n = 8), nilotinib (n = 7), dasatinib (n = 3) and sunitinib (n = 1). The pooled ORR for all inhibitors was 15% (95% confidence interval [CI]: 12-18%). Subgroup analysis revealed the highest ORR (20%; 95% CI: 14-26%) for nilotinib. The ORR for mucosal melanoma was 14% (95% CI: 6-24%) and 22% for acral lentiginous melanoma (95% CI: 14-30%). At least one sAE was reported in 42% of patients (95% CI: 34-50%). Conclusions: c-Kit inhibitors represent a valuable treatment option for patients with KIT mutant melanoma, in particular for mutations of exons 11 and 13. Furthermore, high-quality trials are urgently needed to investigate putative combinations of specific targeted therapies with immunotherapy. (c) 2021 Elsevier Ltd. All rights reserved.
APA:
Steeb, T., Wessely, A., Petzold, A., Kohl, C., Erdmann, M., Berking, C., & Heppt, M. (2021). c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma: a systematic review and one-arm meta-analysis. European Journal of Cancer, 157, 348-357. https://doi.org/10.1016/j.ejca.2021.08.015
MLA:
Steeb, Theresa, et al. "c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma: a systematic review and one-arm meta-analysis." European Journal of Cancer 157 (2021): 348-357.
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